Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4449443..4450074 Replicon chromosome
Accession NZ_CP026831
Organism Shigella dysenteriae strain ATCC 12039

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag C1P71_RS24145 Protein ID WP_001260301.1
Coordinates 4449799..4450074 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag C1P71_RS24140 Protein ID WP_000593555.1
Coordinates 4449443..4449802 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P71_RS26595 (4444683) 4444683..4446215 + 1533 WP_171766310.1 IS3 family transposase -
C1P71_RS26600 (4446212) 4446212..4446592 + 381 WP_284514718.1 PTS transporter subunit IIC -
C1P71_RS24125 (4446735) 4446735..4448243 + 1509 WP_128881439.1 FGGY-family carbohydrate kinase -
C1P71_RS24130 (4448233) 4448233..4448502 + 270 WP_000949583.1 HPr family phosphocarrier protein -
C1P71_RS24135 (4448533) 4448533..4449393 + 861 WP_001603995.1 class II aldolase -
C1P71_RS24140 (4449443) 4449443..4449802 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C1P71_RS24145 (4449799) 4449799..4450074 - 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
C1P71_RS24150 (4450147) 4450147..4451271 - 1125 WP_128881671.1 ABC transporter permease -
C1P71_RS24155 (4451271) 4451271..4454006 - 2736 WP_128881440.1 ribosome-associated ATPase/putative transporter RbbA -
C1P71_RS24160 (4454003) 4454003..4455070 - 1068 WP_128881441.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4440174..4460343 20169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T96306 WP_001260301.1 NZ_CP026831:c4450074-4449799 [Shigella dysenteriae]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T96306 NZ_CP026831:c4450074-4449799 [Shigella dysenteriae]
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT96306 WP_000593555.1 NZ_CP026831:c4449802-4449443 [Shigella dysenteriae]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT96306 NZ_CP026831:c4449802-4449443 [Shigella dysenteriae]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References