Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3579425..3580079 Replicon chromosome
Accession NZ_CP026831
Organism Shigella dysenteriae strain ATCC 12039

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag C1P71_RS19625 Protein ID WP_000244781.1
Coordinates 3579425..3579832 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C1P71_RS19630 Protein ID WP_000354046.1
Coordinates 3579813..3580079 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P71_RS19605 (3575382) 3575382..3577115 - 1734 WP_128881105.1 single-stranded-DNA-specific exonuclease RecJ -
C1P71_RS19610 (3577121) 3577121..3577831 - 711 WP_128881106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P71_RS19615 (3577856) 3577856..3578752 - 897 WP_000806650.1 site-specific tyrosine recombinase XerD -
C1P71_RS19620 (3578864) 3578864..3579385 + 522 WP_032303736.1 flavodoxin FldB -
C1P71_RS19625 (3579425) 3579425..3579832 - 408 WP_000244781.1 protein YgfX Toxin
C1P71_RS19630 (3579813) 3579813..3580079 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C1P71_RS19635 (3580322) 3580322..3581302 + 981 WP_128881107.1 tRNA-modifying protein YgfZ -
C1P71_RS19640 (3581379) 3581379..3582038 - 660 WP_128881108.1 hemolysin III family protein -
C1P71_RS19645 (3582202) 3582202..3582513 - 312 WP_001182963.1 N(4)-acetylcytidine aminohydrolase -
C1P71_RS19650 (3582558) 3582558..3583991 + 1434 WP_141095831.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T96303 WP_000244781.1 NZ_CP026831:c3579832-3579425 [Shigella dysenteriae]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T96303 NZ_CP026831:c3579832-3579425 [Shigella dysenteriae]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGTATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT96303 WP_000354046.1 NZ_CP026831:c3580079-3579813 [Shigella dysenteriae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT96303 NZ_CP026831:c3580079-3579813 [Shigella dysenteriae]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References