Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 2920790..2921495 Replicon chromosome
Accession NZ_CP026831
Organism Shigella dysenteriae strain ATCC 12039

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag C1P71_RS16360 Protein ID WP_128880857.1
Coordinates 2920790..2921176 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag C1P71_RS16365 Protein ID WP_001280945.1
Coordinates 2921166..2921495 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P71_RS16335 (2916000) 2916000..2916896 + 897 Protein_2925 IS3-like element IS600 family transposase -
C1P71_RS16340 (2916943) 2916943..2917521 + 579 Protein_2926 IS3 family transposase -
C1P71_RS16345 (2917552) 2917552..2918532 - 981 Protein_2927 aldose sugar dehydrogenase YliI -
C1P71_RS16350 (2918643) 2918643..2919026 - 384 WP_000497137.1 biofilm formation regulator BssR -
C1P71_RS16355 (2919239) 2919239..2920564 + 1326 WP_000049378.1 30S ribosomal protein S12 methylthiotransferase RimO -
C1P71_RS16360 (2920790) 2920790..2921176 + 387 WP_128880857.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1P71_RS16365 (2921166) 2921166..2921495 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
C1P71_RS16370 (2921622) 2921622..2922466 + 845 WP_128879749.1 IS5-like element ISSfl7 family transposase -
C1P71_RS16375 (2922475) 2922475..2922600 - 126 Protein_2933 transposase -
C1P71_RS16380 (2922777) 2922777..2924005 + 1229 WP_097293774.1 IS3-like element IS2 family transposase -
C1P71_RS16385 (2924016) 2924016..2924402 + 387 Protein_2935 lysozyme RrrD -
C1P71_RS26510 (2924399) 2924399..2924875 + 477 WP_171766292.1 lysis system i-spanin subunit Rz -
C1P71_RS16395 (2924958) 2924958..2925470 - 513 WP_166431503.1 VTT domain-containing protein -
C1P71_RS16400 (2925738) 2925738..2926286 - 549 WP_284514356.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2914120..2949361 35241
- inside IScluster/Tn - - 2914517..2924005 9488


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14327.47 Da        Isoelectric Point: 9.9296

>T96299 WP_128880857.1 NZ_CP026831:2920790-2921176 [Shigella dysenteriae]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRFPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T96299 NZ_CP026831:2920790-2921176 [Shigella dysenteriae]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTCCCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT96299 WP_001280945.1 NZ_CP026831:2921166-2921495 [Shigella dysenteriae]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT96299 NZ_CP026831:2921166-2921495 [Shigella dysenteriae]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References