Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-HTH_XRE |
| Location | 2920790..2921495 | Replicon | chromosome |
| Accession | NZ_CP026831 | ||
| Organism | Shigella dysenteriae strain ATCC 12039 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | C1P71_RS16360 | Protein ID | WP_128880857.1 |
| Coordinates | 2920790..2921176 (+) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | C1P71_RS16365 | Protein ID | WP_001280945.1 |
| Coordinates | 2921166..2921495 (+) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C1P71_RS16335 (2916000) | 2916000..2916896 | + | 897 | Protein_2925 | IS3-like element IS600 family transposase | - |
| C1P71_RS16340 (2916943) | 2916943..2917521 | + | 579 | Protein_2926 | IS3 family transposase | - |
| C1P71_RS16345 (2917552) | 2917552..2918532 | - | 981 | Protein_2927 | aldose sugar dehydrogenase YliI | - |
| C1P71_RS16350 (2918643) | 2918643..2919026 | - | 384 | WP_000497137.1 | biofilm formation regulator BssR | - |
| C1P71_RS16355 (2919239) | 2919239..2920564 | + | 1326 | WP_000049378.1 | 30S ribosomal protein S12 methylthiotransferase RimO | - |
| C1P71_RS16360 (2920790) | 2920790..2921176 | + | 387 | WP_128880857.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| C1P71_RS16365 (2921166) | 2921166..2921495 | + | 330 | WP_001280945.1 | DNA-binding transcriptional regulator | Antitoxin |
| C1P71_RS16370 (2921622) | 2921622..2922466 | + | 845 | WP_128879749.1 | IS5-like element ISSfl7 family transposase | - |
| C1P71_RS16375 (2922475) | 2922475..2922600 | - | 126 | Protein_2933 | transposase | - |
| C1P71_RS16380 (2922777) | 2922777..2924005 | + | 1229 | WP_097293774.1 | IS3-like element IS2 family transposase | - |
| C1P71_RS16385 (2924016) | 2924016..2924402 | + | 387 | Protein_2935 | lysozyme RrrD | - |
| C1P71_RS26510 (2924399) | 2924399..2924875 | + | 477 | WP_171766292.1 | lysis system i-spanin subunit Rz | - |
| C1P71_RS16395 (2924958) | 2924958..2925470 | - | 513 | WP_166431503.1 | VTT domain-containing protein | - |
| C1P71_RS16400 (2925738) | 2925738..2926286 | - | 549 | WP_284514356.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2914120..2949361 | 35241 | |
| - | inside | IScluster/Tn | - | - | 2914517..2924005 | 9488 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14327.47 Da Isoelectric Point: 9.9296
>T96299 WP_128880857.1 NZ_CP026831:2920790-2921176 [Shigella dysenteriae]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRFPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRFPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER
Download Length: 387 bp
>T96299 NZ_CP026831:2920790-2921176 [Shigella dysenteriae]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTCCCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTCCCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
Antitoxin
Download Length: 110 a.a. Molecular weight: 11982.08 Da Isoelectric Point: 10.0101
>AT96299 WP_001280945.1 NZ_CP026831:2921166-2921495 [Shigella dysenteriae]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK
Download Length: 330 bp
>AT96299 NZ_CP026831:2921166-2921495 [Shigella dysenteriae]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|