Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2155949..2156587 Replicon chromosome
Accession NZ_CP026831
Organism Shigella dysenteriae strain ATCC 12039

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag C1P71_RS12210 Protein ID WP_000813794.1
Coordinates 2156411..2156587 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C1P71_RS12205 Protein ID WP_128881617.1
Coordinates 2155949..2156365 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P71_RS12185 (2151160) 2151160..2152101 - 942 WP_001251315.1 ABC transporter permease -
C1P71_RS12190 (2152102) 2152102..2153115 - 1014 WP_128880577.1 ABC transporter ATP-binding protein -
C1P71_RS12195 (2153133) 2153133..2154219 - 1087 Protein_2122 ABC transporter substrate-binding protein -
C1P71_RS12200 (2154464) 2154464..2155870 - 1407 WP_128880578.1 PLP-dependent aminotransferase family protein -
C1P71_RS12205 (2155949) 2155949..2156365 - 417 WP_128881617.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
C1P71_RS12210 (2156411) 2156411..2156587 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
C1P71_RS12215 (2156809) 2156809..2157039 + 231 WP_000494244.1 YncJ family protein -
C1P71_RS12220 (2157131) 2157131..2159076 - 1946 Protein_2127 23S rRNA 5-hydroxycytidine C2501 synthase -
C1P71_RS12225 (2159149) 2159149..2159685 - 537 WP_089646602.1 DNA-binding transcriptional regulator SutR -
C1P71_RS12230 (2159777) 2159777..2161108 + 1332 WP_284515095.1 benzoate/H(+) symporter BenE family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T96298 WP_000813794.1 NZ_CP026831:c2156587-2156411 [Shigella dysenteriae]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T96298 NZ_CP026831:c2156587-2156411 [Shigella dysenteriae]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15278.69 Da        Isoelectric Point: 4.7386

>AT96298 WP_128881617.1 NZ_CP026831:c2156365-2155949 [Shigella dysenteriae]
MRYPVTLTPAPEGGYMVSFMDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT96298 NZ_CP026831:c2156365-2155949 [Shigella dysenteriae]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTATGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References