Detailed information of TA system TA096289

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 244983..245578
• Replicon: chromosome
• Accession: NZ_CP026831
• Organism: Shigella dysenteriae strain ATCC 12039

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: C1P71_RS02465
• Protein ID: WP_000239581.1
• Coordinates: 245228..245578 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: C1P71_RS02460
• Protein ID: WP_128879815.1
• Coordinates: 244983..245234 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P71_RS02450 (240648)	240648..244427	+	3780	WP_128879814.1	autotransporter assembly complex protein TamB	-
C1P71_RS02455 (244430)	244430..244771	+	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
C1P71_RS02460 (244983)	244983..245234	+	252	WP_128879815.1	type II toxin-antitoxin system ChpS family antitoxin	Antitoxin
C1P71_RS02465 (245228)	245228..245578	+	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
C1P71_RS02470 (245657)	245657..246187	-	531	WP_000055075.1	inorganic diphosphatase	-
C1P71_RS02475 (246497)	246497..247453	+	957	WP_128879816.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
C1P71_RS02480 (247586)	247586..249088	+	1503	WP_128879817.1	sugar ABC transporter ATP-binding protein	-
C1P71_RS02485 (249102)	249102..250124	+	1023	WP_128879818.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T96289 WP_000239581.1 NZ_CP026831:245228-245578 [Shigella dysenteriae]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T96289 NZ_CP026831:245228-245578 [Shigella dysenteriae]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9389.67 Da
• Isoelectric Point: 4.4645

>AT96289 WP_128879815.1 NZ_CP026831:244983-245234 [Shigella dysenteriae]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWDKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT96289 NZ_CP026831:244983-245234 [Shigella dysenteriae]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATTTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGATAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: V0SXT4