Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 27244..28019 Replicon plasmid unnamed
Accession NZ_CP026830
Organism Shigella dysenteriae strain ATCC 12039

Toxin (Protein)


Gene name tacT Uniprot ID Q326V1
Locus tag C1P71_RS00190 Protein ID WP_000405248.1
Coordinates 27244..27726 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q7BEG8
Locus tag C1P71_RS00195 Protein ID WP_010921625.1
Coordinates 27717..28019 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P71_RS00150 (22413) 22413..23036 - 624 WP_023308204.1 recombinase family protein -
C1P71_RS26345 (23186) 23186..23395 + 210 Protein_29 DDE-type integrase/transposase/recombinase -
C1P71_RS00160 (23442) 23442..24651 - 1210 Protein_30 IS3 family transposase -
C1P71_RS00165 (24717) 24717..24884 - 168 Protein_31 transposase -
C1P71_RS00170 (24925) 24925..25266 - 342 Protein_32 transposase DNA-binding-containing protein -
C1P71_RS00175 (25245) 25245..25355 - 111 Protein_33 transposase -
C1P71_RS26205 (25430) 25430..25687 + 258 Protein_34 transposase -
C1P71_RS00180 (25755) 25755..26906 + 1152 WP_141095823.1 IS30-like element IS30 family transposase -
C1P71_RS00185 (26916) 26916..27176 - 261 Protein_36 transposase -
C1P71_RS00190 (27244) 27244..27726 - 483 WP_000405248.1 GNAT family N-acetyltransferase Toxin
C1P71_RS00195 (27717) 27717..28019 - 303 WP_010921625.1 DUF1778 domain-containing protein Antitoxin
C1P71_RS00200 (28433) 28433..29149 - 717 Protein_39 IS21-like element IS100kyp family helper ATPase IstB -
C1P71_RS00210 (29347) 29347..30556 + 1210 Protein_40 IS3 family transposase -
C1P71_RS00220 (30797) 30797..31641 + 845 WP_128879669.1 IS5-like element ISSfl7 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ospC2 / ospE2 / ospC1 / ospD3/senA / ospG / ipaH9.8 / virA / icsA/virG / ospI / nleE / icsP/sopA / ospB / ospD2 / ospF / ospD1 / ipgB2 / ipaH4.5 / ipaH9.8 1..181100 181100
- inside IScluster/Tn - ospC2 2925..38092 35167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(29-149)

Antitoxin

Vibrio phage ICP1, Orf50

(19-94)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17736.50 Da        Isoelectric Point: 7.0382

>T96287 WP_000405248.1 NZ_CP026830:c27726-27244 [Shigella dysenteriae]
MEINVTAPALLTDEHILQPFDCGNEVLSNWLRGRAMKNQMLNASRTFVICLEDTLRVVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCTQGHGFGKWLLSDAIHRVVNLADQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPNTLFYKV

Download         Length: 483 bp

>T96287 NZ_CP026830:c27726-27244 [Shigella dysenteriae]
ATGGAAATAAATGTCACCGCGCCAGCATTGTTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCTCGCACGTTCGTTATTTGCTTGGAGGATA
CTTTACGTGTTGTGGGATACTACTCATTAGCTACTGGTTCCGTCACTCATGCCGAGCTTGGTCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTCCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTACCCAGGGGCATGGTTTCGGTAAATG
GCTACTAAGTGATGCCATTCACCGGGTTGTCAATCTGGCTGATCAGGTTGGCATTAAGGCTGTTATGGTACATGCAATTG
ATGATGACGCCAGAGCATTTTATGAGCGTTTTGGTTTTGTTCAGTCAGTTGTGGCACCTAATACCTTGTTTTATAAAGTC
TGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11689.28 Da        Isoelectric Point: 4.9167

>AT96287 WP_010921625.1 NZ_CP026830:c28019-27717 [Shigella dysenteriae]
MEVFMSTAASVRKTPREHQINIRATDEERAVIDYAASLVNKNRTDFIMELAYQEAKNIILDQRLFVLDNERYDSFITQLE
APVQNAEGRERLMAVKPEWK

Download         Length: 303 bp

>AT96287 NZ_CP026830:c28019-27717 [Shigella dysenteriae]
ATGGAGGTTTTTATGTCTACAGCTGCAAGCGTCCGTAAAACACCGCGAGAACATCAGATTAACATCCGGGCAACTGATGA
GGAACGAGCCGTTATTGATTATGCTGCGAGCTTGGTCAATAAGAACCGTACCGATTTCATCATGGAACTGGCGTACCAGG
AAGCTAAAAACATTATCCTGGATCAACGTTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAA
GCTCCTGTGCAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NWA7

Antitoxin

Source ID Structure
AlphaFold DB Q7BEG8

References