Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/ElaA-DUF1778 |
| Location | 15799..16556 | Replicon | plasmid unnamed |
| Accession | NZ_CP026830 | ||
| Organism | Shigella dysenteriae strain ATCC 12039 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | C1P71_RS00120 | Protein ID | WP_128879667.1 |
| Coordinates | 16071..16556 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | Q31SN8 |
| Locus tag | C1P71_RS00115 | Protein ID | WP_011114751.1 |
| Coordinates | 15799..16083 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C1P71_RS00075 (11745) | 11745..12641 | + | 897 | Protein_13 | IS3-like element IS600 family transposase | - |
| C1P71_RS26620 (12688) | 12688..12798 | + | 111 | Protein_14 | hypothetical protein | - |
| C1P71_RS00085 (12805) | 12805..13956 | - | 1152 | WP_001254927.1 | IS30-like element IS30 family transposase | - |
| C1P71_RS26625 (13953) | 13953..14039 | - | 87 | Protein_16 | hypothetical protein | - |
| C1P71_RS00090 (14021) | 14021..14281 | - | 261 | Protein_17 | transposase | - |
| C1P71_RS00095 (14345) | 14345..14479 | + | 135 | Protein_18 | transposase domain-containing protein | - |
| C1P71_RS26340 (14733) | 14733..14897 | - | 165 | WP_001346193.1 | hypothetical protein | - |
| C1P71_RS00115 (15799) | 15799..16083 | + | 285 | WP_011114751.1 | DUF1778 domain-containing protein | Antitoxin |
| C1P71_RS00120 (16071) | 16071..16556 | + | 486 | WP_128879667.1 | GNAT family N-acetyltransferase | Toxin |
| C1P71_RS00125 (16906) | 16906..17750 | + | 845 | WP_094096542.1 | IS5-like element ISSfl7 family transposase | - |
| C1P71_RS00130 (17761) | 17761..18012 | + | 252 | Protein_23 | IS3 family transposase | - |
| C1P71_RS00135 (18087) | 18087..18656 | - | 570 | Protein_24 | Tn3 family transposase | - |
| C1P71_RS00140 (18756) | 18756..19984 | + | 1229 | WP_171766245.1 | IS3-like element IS2 family transposase | - |
| C1P71_RS26630 (19909) | 19909..21525 | - | 1617 | WP_284514258.1 | Tn3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ospC2 / ospE2 / ospC1 / ospD3/senA / ospG / ipaH9.8 / virA / icsA/virG / ospI / nleE / icsP/sopA / ospB / ospD2 / ospF / ospD1 / ipgB2 / ipaH4.5 / ipaH9.8 | 1..181100 | 181100 | |
| - | inside | IScluster/Tn | - | ospC2 | 2925..38092 | 35167 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17726.56 Da Isoelectric Point: 10.1083
>T96286 WP_128879667.1 NZ_CP026830:16071-16556 [Shigella dysenteriae]
MGCVTAPEPLSSFHQVAEFVSGEAVLDEWLKQKGLKNQAIGATRTFVVCRKGTQQIVGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVRRCYRVAENIGVRAIMVHALTENAKQFYIHHGFKPSKTQVQTLFLKLP
Q
MGCVTAPEPLSSFHQVAEFVSGEAVLDEWLKQKGLKNQAIGATRTFVVCRKGTQQIVGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVRRCYRVAENIGVRAIMVHALTENAKQFYIHHGFKPSKTQVQTLFLKLP
Q
Download Length: 486 bp
>T96286 NZ_CP026830:16071-16556 [Shigella dysenteriae]
ATGGGATGTGTAACTGCACCAGAACCTTTATCCTCATTTCATCAGGTCGCTGAATTTGTCAGCGGTGAAGCTGTACTTGA
TGAATGGTTAAAGCAGAAGGGGCTAAAAAATCAGGCAATCGGAGCCACCCGGACTTTTGTTGTATGCAGAAAAGGTACGC
AACAAATAGTCGGTTTTTACTCACTGGCCACTGGTAGTGTCAATCATACAGAAGCTACAGGTAACCTTCGGCGCAATATG
CCAGACCCCATTCCTGTAATTATACTTGCACGCCTGGCTGTAGATGTGTCATTTCGAGGAAAAGGGCTTGGCGCGGATTT
ACTTCATGATGCAGTTCGTCGTTGTTACAGGGTTGCCGAAAATATCGGTGTGCGTGCAATTATGGTTCATGCGCTTACGG
AAAACGCAAAACAGTTTTATATTCATCATGGTTTTAAGCCATCAAAAACTCAGGTGCAAACATTGTTTCTTAAACTCCCT
CAATAG
ATGGGATGTGTAACTGCACCAGAACCTTTATCCTCATTTCATCAGGTCGCTGAATTTGTCAGCGGTGAAGCTGTACTTGA
TGAATGGTTAAAGCAGAAGGGGCTAAAAAATCAGGCAATCGGAGCCACCCGGACTTTTGTTGTATGCAGAAAAGGTACGC
AACAAATAGTCGGTTTTTACTCACTGGCCACTGGTAGTGTCAATCATACAGAAGCTACAGGTAACCTTCGGCGCAATATG
CCAGACCCCATTCCTGTAATTATACTTGCACGCCTGGCTGTAGATGTGTCATTTCGAGGAAAAGGGCTTGGCGCGGATTT
ACTTCATGATGCAGTTCGTCGTTGTTACAGGGTTGCCGAAAATATCGGTGTGCGTGCAATTATGGTTCATGCGCTTACGG
AAAACGCAAAACAGTTTTATATTCATCATGGTTTTAAGCCATCAAAAACTCAGGTGCAAACATTGTTTCTTAAACTCCCT
CAATAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10871.52 Da Isoelectric Point: 4.6812
>AT96286 WP_011114751.1 NZ_CP026830:15799-16083 [Shigella dysenteriae]
MIYGGFMKSGVQLNLRARESQRILIDAAAEILHKSRTDFILEMACKAAEDVILDRRVFNFNDRQYEEFIEMLDAPVADDP
AIEKLLARKPQWDV
MIYGGFMKSGVQLNLRARESQRILIDAAAEILHKSRTDFILEMACKAAEDVILDRRVFNFNDRQYEEFIEMLDAPVADDP
AIEKLLARKPQWDV
Download Length: 285 bp
>AT96286 NZ_CP026830:15799-16083 [Shigella dysenteriae]
ATGATATACGGAGGCTTTATGAAATCAGGTGTTCAGCTCAATCTCAGAGCAAGAGAATCACAGCGGATACTCATTGATGC
TGCTGCAGAAATTCTTCATAAGTCGCGTACAGATTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATGTTATTCTCG
ACCGGCGGGTGTTTAATTTTAATGACAGGCAATATGAAGAGTTCATTGAAATGCTTGATGCTCCGGTTGCAGATGATCCT
GCCATCGAAAAATTGCTGGCAAGGAAACCTCAATGGGATGTGTAA
ATGATATACGGAGGCTTTATGAAATCAGGTGTTCAGCTCAATCTCAGAGCAAGAGAATCACAGCGGATACTCATTGATGC
TGCTGCAGAAATTCTTCATAAGTCGCGTACAGATTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATGTTATTCTCG
ACCGGCGGGTGTTTAATTTTAATGACAGGCAATATGAAGAGTTCATTGAAATGCTTGATGCTCCGGTTGCAGATGATCCT
GCCATCGAAAAATTGCTGGCAAGGAAACCTCAATGGGATGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|