Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 131399..131924 Replicon plasmid unnamed
Accession NZ_CP026829
Organism Shigella dysenteriae strain ATCC 12037

Toxin (Protein)


Gene name ccdB Uniprot ID Q326Z8
Locus tag C1P70_RS25405 Protein ID WP_001159860.1
Coordinates 131399..131704 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID Q7BEK0
Locus tag C1P70_RS25410 Protein ID WP_000813626.1
Coordinates 131706..131924 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P70_RS26985 127239..127391 + 153 Protein_157 hypothetical protein -
C1P70_RS25375 127443..128139 + 697 Protein_158 IS1 family transposase -
C1P70_RS25380 128157..128640 - 484 Protein_159 type III secretion system effector protein kinase OspG -
C1P70_RS26990 128723..128892 - 170 Protein_160 type II toxin-antitoxin system toxin YacB -
C1P70_RS25390 128892..129161 - 270 WP_000079956.1 type II toxin-antitoxin system antitoxin YacA -
C1P70_RS25395 129369..131006 - 1638 WP_129593020.1 T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -
C1P70_RS25400 131268..131375 - 108 WP_023592908.1 transposase domain-containing protein -
C1P70_RS25405 131399..131704 - 306 WP_001159860.1 type II toxin-antitoxin system toxin CcdB Toxin
C1P70_RS25410 131706..131924 - 219 WP_000813626.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
C1P70_RS25420 132517..132789 + 273 WP_000019158.1 hypothetical protein -
C1P70_RS25425 132884..134097 + 1214 Protein_167 IS3 family transposase -
C1P70_RS25435 134161..135291 + 1131 WP_050546159.1 IS91 family transposase -
C1P70_RS25440 135486..136577 - 1092 Protein_169 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ospC3 / ipaH4.5 / ipaH7.8 / ospD3/senA / ospC1 / senB / ospE2 / ipaH1.4 / ospI / ipgB2 / ospD1 / ospF / ospD2 / ospB / icsP/sopA / nleE / ospC2 / ospG / ipaH9.8 / ipaJ / ipaA / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / virA / icsA/virG / icsA/virG / papC 1..216328 216328
- inside IScluster/Tn - ospG / ipaH9.8 117721..161808 44087


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11736.59 Da        Isoelectric Point: 6.4674

>T96284 WP_001159860.1 NZ_CP026829:c131704-131399 [Shigella dysenteriae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T96284 NZ_CP026829:c131704-131399 [Shigella dysenteriae]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGACGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACTGATATGGCCAGTGTGCCGATCTTCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8333.36 Da        Isoelectric Point: 6.2838

>AT96284 WP_000813626.1 NZ_CP026829:c131924-131706 [Shigella dysenteriae]
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT96284 NZ_CP026829:c131924-131706 [Shigella dysenteriae]
ATGAAGCAGCGTATTACTGTCACTATAGACAGTGACAGCTATCAGTTACTTAAATCCGCAAACGTGAATATCTCAGGCCT
GGTAAATACGGCCATGCAAAAAGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCTGAAAATCAGCAGGGGATGGCTG
AGATCGCCCGTTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTN3

Antitoxin

Source ID Structure
AlphaFold DB Q7BEK0

References