Detailed information of TA system TA096260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 418897..419528
• Replicon: chromosome
• Accession: NZ_CP026828
• Organism: Shigella dysenteriae strain ATCC 12037

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C1P70_RS02285
• Protein ID: WP_134806881.1
• Coordinates: 418897..419172 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q31VE4
• Locus tag: C1P70_RS02290
• Protein ID: WP_000593554.1
• Coordinates: 419169..419528 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P70_RS02270 (413901)	413901..414968	+	1068	WP_000361467.1	HlyD family secretion protein	-
C1P70_RS02275 (414965)	414965..417700	+	2736	WP_000149136.1	ribosome-associated ATPase/putative transporter RbbA	-
C1P70_RS02280 (417700)	417700..418824	+	1125	WP_001216257.1	ABC transporter permease	-
C1P70_RS02285 (418897)	418897..419172	+	276	WP_134806881.1	type II toxin-antitoxin system HicA family toxin	Toxin
C1P70_RS02290 (419169)	419169..419528	+	360	WP_000593554.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C1P70_RS02295 (419648)	419648..420049	-	402	WP_001190062.1	nickel-responsive transcriptional regulator NikR	-
C1P70_RS02300 (420055)	420055..420861	-	807	WP_000173706.1	nickel import ATP-binding protein NikE	-
C1P70_RS02305 (420858)	420858..421622	-	765	WP_001136222.1	nickel import ATP-binding protein NikD	-
C1P70_RS02310 (421622)	421622..422455	-	834	WP_001008964.1	nickel ABC transporter permease subunit NikC	-
C1P70_RS02315 (422452)	422452..423396	-	945	WP_000947068.1	nickel ABC transporter permease subunit NikB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-80)

Antitoxin

• Uncharacterised protein family HicB (60-112)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10171.88 Da
• Isoelectric Point: 10.5506

>T96260 WP_134806881.1 NZ_CP026828:418897-419172 [Shigella dysenteriae]
MRTKVQALQKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Nucleotide

• Length: 276 bp

>T96260 NZ_CP026828:418897-419172 [Shigella dysenteriae]
ATGAGAACCAAGGTACAGGCTTTACAGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13359.25 Da
• Isoelectric Point: 4.8838

>AT96260 WP_000593554.1 NZ_CP026828:419169-419528 [Shigella dysenteriae]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Nucleotide

• Length: 360 bp

>AT96260 NZ_CP026828:419169-419528 [Shigella dysenteriae]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A6H2GM94