Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3097795..3098449 Replicon chromosome
Accession NZ_CP026827
Organism Shigella dysenteriae strain ATCC 12021

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag C5B75_RS17590 Protein ID WP_000244777.1
Coordinates 3098042..3098449 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C5B75_RS17585 Protein ID WP_000354046.1
Coordinates 3097795..3098061 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B75_RS17560 (3092964) 3092964..3093707 + 744 WP_000951948.1 SDR family oxidoreductase -
C5B75_RS17565 (3093764) 3093764..3095197 - 1434 WP_141095385.1 6-phospho-beta-glucosidase BglA -
C5B75_RS17570 (3095242) 3095242..3095553 + 312 WP_001182947.1 N(4)-acetylcytidine aminohydrolase -
C5B75_RS17575 (3095717) 3095717..3096376 + 660 WP_000250274.1 hemolysin III family protein -
C5B75_RS17580 (3096572) 3096572..3097552 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
C5B75_RS17585 (3097795) 3097795..3098061 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C5B75_RS17590 (3098042) 3098042..3098449 + 408 WP_000244777.1 protein YgfX Toxin
C5B75_RS17595 (3098489) 3098489..3099010 - 522 WP_001055874.1 flavodoxin FldB -
C5B75_RS17600 (3099122) 3099122..3100018 + 897 WP_059268127.1 site-specific tyrosine recombinase XerD -
C5B75_RS17605 (3100042) 3100042..3100752 + 711 WP_128875377.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C5B75_RS17610 (3100758) 3100758..3102491 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T96254 WP_000244777.1 NZ_CP026827:3098042-3098449 [Shigella dysenteriae]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T96254 NZ_CP026827:3098042-3098449 [Shigella dysenteriae]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAAGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT96254 WP_000354046.1 NZ_CP026827:3097795-3098061 [Shigella dysenteriae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT96254 NZ_CP026827:3097795-3098061 [Shigella dysenteriae]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References