Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 58913..59430 | Replicon | plasmid unnamed |
| Accession | NZ_CP026826 | ||
| Organism | Shigella dysenteriae strain ATCC 12021 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | C5B75_RS00425 | Protein ID | WP_119170698.1 |
| Coordinates | 59197..59430 (+) | Length | 78 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A0M1UJH5 |
| Locus tag | C5B75_RS00420 | Protein ID | WP_038341659.1 |
| Coordinates | 58913..59197 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C5B75_RS00375 | 55430..55591 | - | 162 | Protein_67 | transposase | - |
| C5B75_RS00380 | 55679..55948 | - | 270 | Protein_68 | transposase | - |
| C5B75_RS25290 | 56063..56701 | - | 639 | WP_000607008.1 | type III secretion system effector OspI | - |
| C5B75_RS00390 | 56860..57330 | - | 471 | Protein_70 | IS1 family transposase | - |
| C5B75_RS00400 | 57666..57851 | + | 186 | Protein_71 | ATP-binding protein | - |
| C5B75_RS00405 | 57951..58160 | - | 210 | Protein_72 | peptidoglycan-binding protein | - |
| C5B75_RS00410 | 58210..58461 | - | 252 | WP_000433928.1 | transporter | - |
| C5B75_RS00420 | 58913..59197 | + | 285 | WP_038341659.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| C5B75_RS00425 | 59197..59430 | + | 234 | WP_119170698.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| C5B75_RS25295 | 60020..60226 | + | 207 | WP_168177808.1 | hypothetical protein | - |
| C5B75_RS00435 | 60177..60476 | - | 300 | Protein_78 | hypothetical protein | - |
| C5B75_RS00445 | 60959..61801 | + | 843 | WP_000931198.1 | polysaccharide deacetylase family protein | - |
| C5B75_RS00450 | 61804..62892 | + | 1089 | WP_005027207.1 | putative hexosyltransferase CapU | - |
| C5B75_RS00455 | 62897..63847 | + | 951 | WP_012449328.1 | virulence factor VirK | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ipaC / ipaC / ipaB / ipaB / ipaB / ipgC / ipgC / ipgB1 / icsB / icsB / ipgD / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / virA / icsA/virG / papC / ospI / ospC2 / nleE / icsP/sopA / ospB / ospC4 / ospC4 / ospC2 / ospD2 / ospF / ospD1 / ipgB2 / ospE2 / ospC1 / ospD3/senA / ipaH7.8 / ipaH4.5 / ipaH1.4 / ospC3 / ipaJ / ipaA / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / mxiA / mxiA / spa15 / spa15 / spa47 / spa47 / spa13 | 1..224352 | 224352 | |
| - | inside | IScluster/Tn | - | ospI | 40205..59927 | 19722 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 78 a.a. Molecular weight: 8928.43 Da Isoelectric Point: 9.6576
>T96233 WP_119170698.1 NZ_CP026826:59197-59430 [Shigella dysenteriae]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRVMTPTY
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRVMTPTY
Download Length: 234 bp
>T96233 NZ_CP026826:59197-59430 [Shigella dysenteriae]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGGGTAATGACTCCAACTTACTGA
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGGGTAATGACTCCAACTTACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10444.88 Da Isoelectric Point: 5.5648
>AT96233 WP_038341659.1 NZ_CP026826:58913-59197 [Shigella dysenteriae]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEECNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEECNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
Download Length: 285 bp
>AT96233 NZ_CP026826:58913-59197 [Shigella dysenteriae]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGTGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGTGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|