Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 122089..122648 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP026820 | ||
| Organism | Shigella dysenteriae strain 96-265 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D2AJT2 |
| Locus tag | C1P77_RS26240 | Protein ID | WP_000421262.1 |
| Coordinates | 122089..122364 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q327A8 |
| Locus tag | C1P77_RS26245 | Protein ID | WP_001178088.1 |
| Coordinates | 122364..122648 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C1P77_RS26210 | 117091..118304 | + | 1214 | WP_167544920.1 | IS3 family transposase | - |
| C1P77_RS26220 | 118368..119498 | + | 1131 | WP_050546159.1 | IS91 family transposase | - |
| C1P77_RS26225 | 119693..120784 | - | 1092 | Protein_140 | IS66 family transposase | - |
| C1P77_RS26230 | 120792..121359 | + | 568 | Protein_141 | plasmid segregation protein ParM | - |
| C1P77_RS27545 | 121362..121544 | + | 183 | WP_241547534.1 | plasmid partitioning/stability family protein | - |
| C1P77_RS27550 | 121820..121957 | + | 138 | WP_000766699.1 | hypothetical protein | - |
| C1P77_RS26240 | 122089..122364 | - | 276 | WP_000421262.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| C1P77_RS26245 | 122364..122648 | - | 285 | WP_001178088.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| C1P77_RS26255 | 123100..123351 | + | 252 | WP_000433928.1 | transporter | - |
| C1P77_RS26260 | 123401..123610 | + | 210 | Protein_147 | peptidoglycan-binding protein | - |
| C1P77_RS27555 | 123692..123793 | - | 102 | Protein_148 | ATP-binding protein | - |
| C1P77_RS26265 | 123945..124301 | + | 357 | WP_005041107.1 | transposase | - |
| C1P77_RS26270 | 124298..124648 | + | 351 | WP_000624671.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| C1P77_RS26275 | 124679..126271 | + | 1593 | WP_001072392.1 | IS66 family transposase | - |
| C1P77_RS27560 | 126278..126409 | - | 132 | Protein_152 | ATP-binding protein | - |
| C1P77_RS26285 | 126628..127302 | + | 675 | WP_046891833.1 | IS66-like element accessory protein TnpA | - |
| C1P77_RS26290 | 127299..127463 | + | 165 | Protein_154 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ospI / ospE2 / ipaH1.4 / ospC1 / ospD3/senA / ipaH7.8 / ipaH4.5 / ospC3 / ipaJ / ipaA / ipaA / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / virA / virA / icsA/virG / papC / ipaH9.8 / ospG / ospC2 / nleE / icsP/sopA / icsP/sopA / ospB / ospC4 / ospD2 / ospF / ospD1 / ipgB2 | 1..195489 | 195489 | |
| - | inside | IScluster/Tn | - | ipaH9.8 / ospG | 108979..141672 | 32693 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10766.48 Da Isoelectric Point: 9.9324
>T96229 WP_000421262.1 NZ_CP026820:c122364-122089 [Shigella dysenteriae]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWHTRENR
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T96229 NZ_CP026820:c122364-122089 [Shigella dysenteriae]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACAGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAGAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACAGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAGAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10497.93 Da Isoelectric Point: 6.2150
>AT96229 WP_001178088.1 NZ_CP026820:c122648-122364 [Shigella dysenteriae]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
Download Length: 285 bp
>AT96229 NZ_CP026820:c122648-122364 [Shigella dysenteriae]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A822PVM3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q327A8 |