Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3462766..3463397 Replicon chromosome
Accession NZ_CP026819
Organism Shigella dysenteriae strain 96-265

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag C1P77_RS19055 Protein ID WP_001259385.1
Coordinates 3463122..3463397 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3P6LLN4
Locus tag C1P77_RS19050 Protein ID WP_000593559.1
Coordinates 3462766..3463125 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P77_RS19025 (3458898) 3458898..3459842 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
C1P77_RS19030 (3459839) 3459839..3460672 + 834 WP_001008964.1 nickel ABC transporter permease subunit NikC -
C1P77_RS19035 (3460672) 3460672..3461436 + 765 WP_001136222.1 nickel import ATP-binding protein NikD -
C1P77_RS19040 (3461433) 3461433..3462239 + 807 WP_000173710.1 nickel import ATP-binding protein NikE -
C1P77_RS19045 (3462245) 3462245..3462646 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
C1P77_RS19050 (3462766) 3462766..3463125 - 360 WP_000593559.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C1P77_RS19055 (3463122) 3463122..3463397 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
C1P77_RS19060 (3463470) 3463470..3464594 - 1125 WP_001216257.1 ABC transporter permease -
C1P77_RS19065 (3464594) 3464594..3467329 - 2736 WP_000149136.1 ribosome-associated ATPase/putative transporter RbbA -
C1P77_RS19070 (3467326) 3467326..3468393 - 1068 WP_000361465.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T96223 WP_001259385.1 NZ_CP026819:c3463397-3463122 [Shigella dysenteriae]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T96223 NZ_CP026819:c3463397-3463122 [Shigella dysenteriae]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13373.27 Da        Isoelectric Point: 4.8838

>AT96223 WP_000593559.1 NZ_CP026819:c3463125-3462766 [Shigella dysenteriae]
MIKLKTPNTMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT96223 NZ_CP026819:c3463125-3462766 [Shigella dysenteriae]
ATGATCAAACTGAAGACGCCAAACACTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A3P6LLN4

References