Detailed information of TA system TA096221

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2921009..2921844
• Replicon: chromosome
• Accession: NZ_CP026819
• Organism: Shigella dysenteriae strain 96-265

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: C1P77_RS16195
• Protein ID: WP_134800840.1
• Coordinates: 2921467..2921844 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: C1P77_RS16190
• Protein ID: WP_134800841.1
• Coordinates: 2921009..2921377 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P77_RS16160 (2916205)	2916205..2918340	+	2136	Protein_3022	Ag43/Cah family autotransporter adhesin	-
C1P77_RS16165 (2918412)	2918412..2918645	+	234	WP_064986988.1	DUF905 family protein	-
C1P77_RS16170 (2918736)	2918736..2919553	+	818	Protein_3024	DUF932 domain-containing protein	-
C1P77_RS16175 (2919645)	2919645..2920130	+	486	WP_134800842.1	antirestriction protein	-
C1P77_RS16180 (2920145)	2920145..2920621	+	477	WP_047656594.1	RadC family protein	-
C1P77_RS16185 (2920708)	2920708..2920929	+	222	WP_000692350.1	DUF987 domain-containing protein	-
C1P77_RS16190 (2921009)	2921009..2921377	+	369	WP_134800841.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
C1P77_RS16195 (2921467)	2921467..2921844	+	378	WP_134800840.1	TA system toxin CbtA family protein	Toxin
C1P77_RS16200 (2921841)	2921841..2921990	+	150	Protein_3030	DUF5983 family protein	-
C1P77_RS16205 (2922069)	2922069..2922263	+	195	WP_134800885.1	DUF957 domain-containing protein	-
C1P77_RS16210 (2922348)	2922348..2923193	+	846	WP_134805650.1	DUF4942 domain-containing protein	-
C1P77_RS16220 (2923493)	2923493..2923999	+	507	WP_000228937.1	G/U mismatch-specific DNA glycosylase	-
C1P77_RS16225 (2924086)	2924086..2925432	+	1347	WP_005043692.1	IS4-like element IS4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2924104..2925432	1328

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14211.11 Da
• Isoelectric Point: 7.7761

>T96221 WP_134800840.1 NZ_CP026819:2921467-2921844 [Shigella dysenteriae]
MKTLSDTHIREASRCPSPVTVWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTNSQLINSIDILRARRATGLMTRDNYRTVNNITQGKYQEAKR

Nucleotide

• Length: 378 bp

>T96221 NZ_CP026819:2921467-2921844 [Shigella dysenteriae]
ATGAAAACATTATCCGACACACACATACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCGTCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAACACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCAACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGTAAGTATCAGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13583.32 Da
• Isoelectric Point: 5.9562

>AT96221 WP_134800841.1 NZ_CP026819:2921009-2921377 [Shigella dysenteriae]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKT

Nucleotide

• Length: 369 bp

>AT96221 NZ_CP026819:2921009-2921377 [Shigella dysenteriae]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA