Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 98960..99578 Replicon chromosome
Accession NZ_CP026819
Organism Shigella dysenteriae strain 96-265

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag C1P77_RS01040 Protein ID WP_001291435.1
Coordinates 99360..99578 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q325D5
Locus tag C1P77_RS01035 Protein ID WP_000344809.1
Coordinates 98960..99334 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P77_RS01025 (94049) 94049..95242 + 1194 WP_024258559.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C1P77_RS01030 (95265) 95265..98414 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
C1P77_RS01035 (98960) 98960..99334 + 375 WP_000344809.1 Hha toxicity modulator TomB Antitoxin
C1P77_RS01040 (99360) 99360..99578 + 219 WP_001291435.1 HHA domain-containing protein Toxin
C1P77_RS01045 (99750) 99750..100301 + 552 WP_000102546.1 maltose O-acetyltransferase -
C1P77_RS01050 (100417) 100417..100887 + 471 WP_005039856.1 YlaC family protein -
C1P77_RS01060 (101979) 101979..103207 + 1229 WP_167544903.1 IS3-like element IS2 family transposase -
C1P77_RS01065 (103218) 103218..103583 + 366 Protein_111 CSS-motif domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T96204 WP_001291435.1 NZ_CP026819:99360-99578 [Shigella dysenteriae]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T96204 NZ_CP026819:99360-99578 [Shigella dysenteriae]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14583.42 Da        Isoelectric Point: 4.5934

>AT96204 WP_000344809.1 NZ_CP026819:98960-99334 [Shigella dysenteriae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNYGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT96204 NZ_CP026819:98960-99334 [Shigella dysenteriae]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATTATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB Q325D5

References