Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3569006..3569624 Replicon chromosome
Accession NZ_CP026815
Organism Shigella dysenteriae strain 93-119

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag C1P76_RS19100 Protein ID WP_001291435.1
Coordinates 3569006..3569224 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q325D5
Locus tag C1P76_RS19105 Protein ID WP_000344809.1
Coordinates 3569250..3569624 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P76_RS19075 (3565001) 3565001..3565366 - 366 Protein_3692 CSS-motif domain-containing protein -
C1P76_RS19085 (3566706) 3566706..3567403 + 698 WP_134795416.1 IS1-like element IS1SD family transposase -
C1P76_RS19090 (3567697) 3567697..3568167 - 471 WP_005039856.1 YlaC family protein -
C1P76_RS19095 (3568283) 3568283..3568834 - 552 WP_000102546.1 maltose O-acetyltransferase -
C1P76_RS19100 (3569006) 3569006..3569224 - 219 WP_001291435.1 HHA domain-containing protein Toxin
C1P76_RS19105 (3569250) 3569250..3569624 - 375 WP_000344809.1 Hha toxicity modulator TomB Antitoxin
C1P76_RS19110 (3570170) 3570170..3573318 - 3149 Protein_3699 efflux RND transporter permease AcrB -
C1P76_RS19115 (3573341) 3573341..3574534 - 1194 WP_024258559.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T96196 WP_001291435.1 NZ_CP026815:c3569224-3569006 [Shigella dysenteriae]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T96196 NZ_CP026815:c3569224-3569006 [Shigella dysenteriae]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14583.42 Da        Isoelectric Point: 4.5934

>AT96196 WP_000344809.1 NZ_CP026815:c3569624-3569250 [Shigella dysenteriae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNYGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT96196 NZ_CP026815:c3569624-3569250 [Shigella dysenteriae]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATTATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB Q325D5

References