Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 527995..528649 Replicon chromosome
Accession NZ_CP026815
Organism Shigella dysenteriae strain 93-119

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag C1P76_RS02685 Protein ID WP_000244777.1
Coordinates 527995..528402 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C1P76_RS02690 Protein ID WP_000354046.1
Coordinates 528383..528649 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P76_RS02665 (523953) 523953..525685 - 1733 Protein_520 single-stranded-DNA-specific exonuclease RecJ -
C1P76_RS02670 (525691) 525691..526401 - 711 WP_000715205.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P76_RS02675 (526426) 526426..527322 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
C1P76_RS02680 (527434) 527434..527955 + 522 WP_001055874.1 flavodoxin FldB -
C1P76_RS02685 (527995) 527995..528402 - 408 WP_000244777.1 protein YgfX Toxin
C1P76_RS02690 (528383) 528383..528649 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C1P76_RS02695 (528892) 528892..529872 + 981 WP_000886098.1 tRNA-modifying protein YgfZ -
C1P76_RS02700 (529949) 529949..530608 - 660 WP_000250274.1 hemolysin III family protein -
C1P76_RS02705 (530772) 530772..531083 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
C1P76_RS02710 (531128) 531128..532561 + 1434 WP_004986559.1 6-phospho-beta-glucosidase BglA -
C1P76_RS02715 (532618) 532618..533361 - 744 WP_000951947.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T96178 WP_000244777.1 NZ_CP026815:c528402-527995 [Shigella dysenteriae]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T96178 NZ_CP026815:c528402-527995 [Shigella dysenteriae]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGATTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT96178 WP_000354046.1 NZ_CP026815:c528649-528383 [Shigella dysenteriae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT96178 NZ_CP026815:c528649-528383 [Shigella dysenteriae]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References