Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3512011..3512842 Replicon chromosome
Accession NZ_CP026814
Organism Shigella boydii strain 83-578

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag C1P60_RS19145 Protein ID WP_000854814.1
Coordinates 3512468..3512842 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag C1P60_RS19140 Protein ID WP_001285585.1
Coordinates 3512011..3512379 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P60_RS19110 3508158..3508457 - 300 Protein_3444 IS1 family transposase -
C1P60_RS19120 3509770..3510600 + 831 WP_039059216.1 DUF945 domain-containing protein -
C1P60_RS19125 3510682..3511161 + 480 WP_000860059.1 antirestriction protein -
C1P60_RS19130 3511177..3511653 + 477 WP_012421636.1 RadC family protein -
C1P60_RS19135 3511716..3511937 + 222 WP_000692323.1 DUF987 domain-containing protein -
C1P60_RS19140 3512011..3512379 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
C1P60_RS19145 3512468..3512842 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
C1P60_RS19150 3512839..3513033 + 195 WP_000988600.1 hypothetical protein -
C1P60_RS25355 3513046..3513159 + 114 WP_001161660.1 DUF957 domain-containing protein -
C1P60_RS19160 3513548..3514675 + 1128 WP_001063816.1 IS110-like element ISSso6 family transposase -
C1P60_RS19165 3514942..3515181 - 240 Protein_3455 nickel/cobalt efflux protein RcnA -
C1P60_RS19170 3515303..3515575 + 273 WP_000019944.1 Ni(II)/Co(II)-binding transcriptional repressor RcnR -
C1P60_RS19175 3515798..3516586 + 789 WP_001195636.1 hydroxyethylthiazole kinase -
C1P60_RS19180 3516583..3517383 + 801 WP_000822274.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3495556..3514675 19119


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T96159 WP_000854814.1 NZ_CP026814:3512468-3512842 [Shigella boydii]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T96159 NZ_CP026814:3512468-3512842 [Shigella boydii]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT96159 WP_001285585.1 NZ_CP026814:3512011-3512379 [Shigella boydii]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT96159 NZ_CP026814:3512011-3512379 [Shigella boydii]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References