Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 941273..941927 Replicon chromosome
Accession NZ_CP026814
Organism Shigella boydii strain 83-578

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag C1P60_RS05585 Protein ID WP_000244777.1
Coordinates 941273..941680 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2S8DWY8
Locus tag C1P60_RS05590 Protein ID WP_039059554.1
Coordinates 941661..941927 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P60_RS05565 937230..938963 - 1734 WP_000813182.1 single-stranded-DNA-specific exonuclease RecJ -
C1P60_RS05570 938969..939679 - 711 WP_000715205.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P60_RS05575 939704..940600 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
C1P60_RS05580 940712..941233 + 522 WP_001055874.1 flavodoxin FldB -
C1P60_RS05585 941273..941680 - 408 WP_000244777.1 toxin CptA Toxin
C1P60_RS05590 941661..941927 - 267 WP_039059554.1 FAD assembly factor SdhE Antitoxin
C1P60_RS05595 942170..943150 + 981 WP_000886098.1 tRNA-modifying protein YgfZ -
C1P60_RS05600 943346..944005 - 660 WP_000250274.1 hemolysin III family protein -
C1P60_RS05605 944169..944480 - 312 WP_001182969.1 N(4)-acetylcytidine aminohydrolase -
C1P60_RS05610 944525..945958 + 1434 WP_024258645.1 6-phospho-beta-glucosidase BglA -
C1P60_RS05615 946015..946758 - 744 WP_000951947.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T96155 WP_000244777.1 NZ_CP026814:c941680-941273 [Shigella boydii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T96155 NZ_CP026814:c941680-941273 [Shigella boydii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGATTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10577.15 Da        Isoelectric Point: 4.8727

>AT96155 WP_039059554.1 NZ_CP026814:c941927-941661 [Shigella boydii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
WERGPVAI

Download         Length: 267 bp

>AT96155 NZ_CP026814:c941927-941661 [Shigella boydii]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
TGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A2S8DWY8

References