Detailed information of TA system TA096124

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4446470..4447305
• Replicon: chromosome
• Accession: NZ_CP026807
• Organism: Shigella dysenteriae strain 204/96

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: C1P75_RS23525
• Protein ID: WP_134800840.1
• Coordinates: 4446470..4446847 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: C1P75_RS23530
• Protein ID: WP_134800841.1
• Coordinates: 4446937..4447305 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P75_RS23495 (4442882)	4442882..4444228	-	1347	WP_005043692.1	IS4-like element IS4 family transposase	-
C1P75_RS23500 (4444315)	4444315..4444821	-	507	WP_000228937.1	G/U mismatch-specific DNA glycosylase	-
C1P75_RS23510 (4445121)	4445121..4445966	-	846	WP_134805650.1	DUF4942 domain-containing protein	-
C1P75_RS23515 (4446051)	4446051..4446245	-	195	WP_134800885.1	DUF957 domain-containing protein	-
C1P75_RS23520 (4446324)	4446324..4446473	-	150	Protein_4533	DUF5983 family protein	-
C1P75_RS23525 (4446470)	4446470..4446847	-	378	WP_134800840.1	TA system toxin CbtA family protein	Toxin
C1P75_RS23530 (4446937)	4446937..4447305	-	369	WP_134800841.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
C1P75_RS23535 (4447385)	4447385..4447606	-	222	WP_000692350.1	DUF987 domain-containing protein	-
C1P75_RS23540 (4447693)	4447693..4448169	-	477	WP_047656594.1	RadC family protein	-
C1P75_RS23545 (4448184)	4448184..4448669	-	486	WP_134800842.1	antirestriction protein	-
C1P75_RS23550 (4448761)	4448761..4449579	-	819	WP_097308925.1	DUF932 domain-containing protein	-
C1P75_RS23555 (4449670)	4449670..4449903	-	234	WP_064986988.1	DUF905 family protein	-
C1P75_RS23560 (4449975)	4449975..4452110	-	2136	Protein_4541	Ag43/Cah family autotransporter adhesin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4442882..4444210	1328

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14211.11 Da
• Isoelectric Point: 7.7761

>T96124 WP_134800840.1 NZ_CP026807:c4446847-4446470 [Shigella dysenteriae]
MKTLSDTHIREASRCPSPVTVWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTNSQLINSIDILRARRATGLMTRDNYRTVNNITQGKYQEAKR

Nucleotide

• Length: 378 bp

>T96124 NZ_CP026807:c4446847-4446470 [Shigella dysenteriae]
ATGAAAACATTATCCGACACACACATACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCGTCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAACACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCAACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGTAAGTATCAGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13583.32 Da
• Isoelectric Point: 5.9562

>AT96124 WP_134800841.1 NZ_CP026807:c4447305-4446937 [Shigella dysenteriae]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKT

Nucleotide

• Length: 369 bp

>AT96124 NZ_CP026807:c4447305-4446937 [Shigella dysenteriae]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA