96123

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4279097..4279751 Replicon chromosome
Accession NZ_CP026807
Organism Shigella dysenteriae strain 204/96

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag C1P75_RS22625 Protein ID WP_000244777.1
Coordinates 4279097..4279504 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C1P75_RS22630 Protein ID WP_000354046.1
Coordinates 4279485..4279751 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P75_RS22605 (4275054) 4275054..4276787 - 1734 WP_000813209.1 single-stranded-DNA-specific exonuclease RecJ -
C1P75_RS22610 (4276793) 4276793..4277503 - 711 WP_000715205.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P75_RS22615 (4277528) 4277528..4278424 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
C1P75_RS22620 (4278536) 4278536..4279057 + 522 WP_001055874.1 flavodoxin FldB -
C1P75_RS22625 (4279097) 4279097..4279504 - 408 WP_000244777.1 protein YgfX Toxin
C1P75_RS22630 (4279485) 4279485..4279751 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C1P75_RS22635 (4279994) 4279994..4280974 + 981 WP_000886098.1 tRNA-modifying protein YgfZ -
C1P75_RS22640 (4281051) 4281051..4281710 - 660 WP_000250274.1 hemolysin III family protein -
C1P75_RS22645 (4281874) 4281874..4282185 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
C1P75_RS22650 (4282230) 4282230..4283663 + 1434 WP_004986559.1 6-phospho-beta-glucosidase BglA -
C1P75_RS22655 (4283720) 4283720..4284463 - 744 WP_000951947.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T96123 WP_000244777.1 NZ_CP026807:c4279504-4279097 [Shigella dysenteriae]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T96123 NZ_CP026807:c4279504-4279097 [Shigella dysenteriae]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGATTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT96123 WP_000354046.1 NZ_CP026807:c4279751-4279485 [Shigella dysenteriae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT96123 NZ_CP026807:c4279751-4279485 [Shigella dysenteriae]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References