Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3904916..3905547 Replicon chromosome
Accession NZ_CP026807
Organism Shigella dysenteriae strain 204/96

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag C1P75_RS20660 Protein ID WP_001259385.1
Coordinates 3904916..3905191 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3P6LLN4
Locus tag C1P75_RS20665 Protein ID WP_000593559.1
Coordinates 3905188..3905547 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P75_RS20645 (3899920) 3899920..3900987 + 1068 WP_000361465.1 HlyD family secretion protein -
C1P75_RS20650 (3900984) 3900984..3903719 + 2736 WP_000149136.1 ribosome-associated ATPase/putative transporter RbbA -
C1P75_RS20655 (3903719) 3903719..3904843 + 1125 WP_001216257.1 ABC transporter permease -
C1P75_RS20660 (3904916) 3904916..3905191 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
C1P75_RS20665 (3905188) 3905188..3905547 + 360 WP_000593559.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C1P75_RS20670 (3905667) 3905667..3906068 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
C1P75_RS20675 (3906074) 3906074..3906880 - 807 WP_000173710.1 nickel import ATP-binding protein NikE -
C1P75_RS20680 (3906877) 3906877..3907641 - 765 WP_001136222.1 nickel import ATP-binding protein NikD -
C1P75_RS20685 (3907641) 3907641..3908474 - 834 WP_001008964.1 nickel ABC transporter permease subunit NikC -
C1P75_RS20690 (3908471) 3908471..3909415 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T96122 WP_001259385.1 NZ_CP026807:3904916-3905191 [Shigella dysenteriae]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T96122 NZ_CP026807:3904916-3905191 [Shigella dysenteriae]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13373.27 Da        Isoelectric Point: 4.8838

>AT96122 WP_000593559.1 NZ_CP026807:3905188-3905547 [Shigella dysenteriae]
MIKLKTPNTMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT96122 NZ_CP026807:3905188-3905547 [Shigella dysenteriae]
ATGATCAAACTGAAGACGCCAAACACTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A3P6LLN4

References