Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 42508..43067 Replicon plasmid unnamed
Accession NZ_CP026806
Organism Shigella dysenteriae strain 2017C-4522

Toxin (Protein)


Gene name relE Uniprot ID D2AJT2
Locus tag C1P73_RS24580 Protein ID WP_000421262.1
Coordinates 42792..43067 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q327A8
Locus tag C1P73_RS24575 Protein ID WP_001178088.1
Coordinates 42508..42792 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P73_RS24545 38885..40477 - 1593 WP_001072392.1 IS66 family transposase -
C1P73_RS24550 40508..40858 - 351 WP_129593018.1 IS66 family insertion sequence element accessory protein TnpB -
C1P73_RS24555 40855..41211 - 357 WP_000239757.1 transposase -
C1P73_RS25875 41363..41464 + 102 Protein_56 ATP-binding protein -
C1P73_RS24560 41546..41755 - 210 Protein_57 peptidoglycan-binding protein -
C1P73_RS24565 41805..42056 - 252 WP_000433928.1 transporter -
C1P73_RS24575 42508..42792 + 285 WP_001178088.1 ribbon-helix-helix domain-containing protein Antitoxin
C1P73_RS24580 42792..43067 + 276 WP_000421262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1P73_RS25230 43199..43336 - 138 WP_000766699.1 hypothetical protein -
C1P73_RS25880 43612..43794 - 183 WP_241547534.1 plasmid partitioning/stability family protein -
C1P73_RS24590 43797..44363 - 567 Protein_63 plasmid segregation protein ParM -
C1P73_RS24600 44371..45462 + 1092 Protein_64 IS66 family transposase -
C1P73_RS24605 45657..46787 - 1131 WP_050546159.1 IS91 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ospC2 / nleE / icsP/sopA / icsP/sopA / ospB / ipaH9.8 / ospG 1..69966 69966
- inside IScluster/Tn - ospC2 / nleE / icsP/sopA / icsP/sopA / ospB / ipaH9.8 / ospG 5848..54437 48589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10766.48 Da        Isoelectric Point: 9.9324

>T96101 WP_000421262.1 NZ_CP026806:42792-43067 [Shigella dysenteriae]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T96101 NZ_CP026806:42792-43067 [Shigella dysenteriae]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACAGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAGAACAGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10497.93 Da        Isoelectric Point: 6.2150

>AT96101 WP_001178088.1 NZ_CP026806:42508-42792 [Shigella dysenteriae]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR

Download         Length: 285 bp

>AT96101 NZ_CP026806:42508-42792 [Shigella dysenteriae]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822PVM3

Antitoxin

Source ID Structure
AlphaFold DB Q327A8

References