Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 2625126..2625757 | Replicon | chromosome |
Accession | NZ_CP026805 | ||
Organism | Shigella dysenteriae strain 2017C-4522 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | U9Y2A7 |
Locus tag | C1P73_RS14165 | Protein ID | WP_001259385.1 |
Coordinates | 2625482..2625757 (-) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A3P6LLN4 |
Locus tag | C1P73_RS14160 | Protein ID | WP_000593559.1 |
Coordinates | 2625126..2625485 (-) | Length | 120 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C1P73_RS14135 (2621258) | 2621258..2622202 | + | 945 | WP_000947068.1 | nickel ABC transporter permease subunit NikB | - |
C1P73_RS14140 (2622199) | 2622199..2623032 | + | 834 | WP_001008964.1 | nickel ABC transporter permease subunit NikC | - |
C1P73_RS14145 (2623032) | 2623032..2623796 | + | 765 | WP_001136222.1 | nickel import ATP-binding protein NikD | - |
C1P73_RS14150 (2623793) | 2623793..2624599 | + | 807 | WP_000173706.1 | nickel import ATP-binding protein NikE | - |
C1P73_RS14155 (2624605) | 2624605..2625006 | + | 402 | WP_001190062.1 | nickel-responsive transcriptional regulator NikR | - |
C1P73_RS14160 (2625126) | 2625126..2625485 | - | 360 | WP_000593559.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
C1P73_RS14165 (2625482) | 2625482..2625757 | - | 276 | WP_001259385.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
C1P73_RS14170 (2625830) | 2625830..2626954 | - | 1125 | WP_001216257.1 | ABC transporter permease | - |
C1P73_RS14175 (2626954) | 2626954..2629689 | - | 2736 | WP_000149136.1 | ribosome-associated ATPase/putative transporter RbbA | - |
C1P73_RS14180 (2629686) | 2629686..2630753 | - | 1068 | WP_000361465.1 | HlyD family secretion protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10199.94 Da Isoelectric Point: 10.7076
>T96093 WP_001259385.1 NZ_CP026805:c2625757-2625482 [Shigella dysenteriae]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
Download Length: 276 bp
>T96093 NZ_CP026805:c2625757-2625482 [Shigella dysenteriae]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13373.27 Da Isoelectric Point: 4.8838
>AT96093 WP_000593559.1 NZ_CP026805:c2625485-2625126 [Shigella dysenteriae]
MIKLKTPNTMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
MIKLKTPNTMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
Download Length: 360 bp
>AT96093 NZ_CP026805:c2625485-2625126 [Shigella dysenteriae]
ATGATCAAACTGAAGACGCCAAACACTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
ATGATCAAACTGAAGACGCCAAACACTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4P7TTW8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3P6LLN4 |