Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/-
Location 2625126..2625757 Replicon chromosome
Accession NZ_CP026805
Organism Shigella dysenteriae strain 2017C-4522

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag C1P73_RS14165 Protein ID WP_001259385.1
Coordinates 2625482..2625757 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3P6LLN4
Locus tag C1P73_RS14160 Protein ID WP_000593559.1
Coordinates 2625126..2625485 (-) Length 120 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P73_RS14135 (2621258) 2621258..2622202 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
C1P73_RS14140 (2622199) 2622199..2623032 + 834 WP_001008964.1 nickel ABC transporter permease subunit NikC -
C1P73_RS14145 (2623032) 2623032..2623796 + 765 WP_001136222.1 nickel import ATP-binding protein NikD -
C1P73_RS14150 (2623793) 2623793..2624599 + 807 WP_000173706.1 nickel import ATP-binding protein NikE -
C1P73_RS14155 (2624605) 2624605..2625006 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
C1P73_RS14160 (2625126) 2625126..2625485 - 360 WP_000593559.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C1P73_RS14165 (2625482) 2625482..2625757 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
C1P73_RS14170 (2625830) 2625830..2626954 - 1125 WP_001216257.1 ABC transporter permease -
C1P73_RS14175 (2626954) 2626954..2629689 - 2736 WP_000149136.1 ribosome-associated ATPase/putative transporter RbbA -
C1P73_RS14180 (2629686) 2629686..2630753 - 1068 WP_000361465.1 HlyD family secretion protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(30-80)

Antitoxin

(60-112)


Sequences


Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T96093 WP_001259385.1 NZ_CP026805:c2625757-2625482 [Shigella dysenteriae]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T96093 NZ_CP026805:c2625757-2625482 [Shigella dysenteriae]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13373.27 Da        Isoelectric Point: 4.8838

>AT96093 WP_000593559.1 NZ_CP026805:c2625485-2625126 [Shigella dysenteriae]
MIKLKTPNTMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT96093 NZ_CP026805:c2625485-2625126 [Shigella dysenteriae]
ATGATCAAACTGAAGACGCCAAACACTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8


Antitoxin

Source ID Structure
AlphaFold DB A0A3P6LLN4

References