Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1280434..1280918 Replicon chromosome
Accession NZ_CP026802
Organism Shigella sonnei strain ATCC 29930

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag C1P89_RS06790 Protein ID WP_014334020.1
Coordinates 1280628..1280918 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag C1P89_RS06785 Protein ID WP_005142544.1
Coordinates 1280434..1280628 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P89_RS06745 (1275629) 1275629..1275985 - 357 WP_005140877.1 hypothetical protein -
C1P89_RS06750 (1276043) 1276043..1276465 - 423 WP_001151171.1 DUF977 family protein -
C1P89_RS06755 (1276481) 1276481..1277206 - 726 WP_000450631.1 DUF1627 domain-containing protein -
C1P89_RS06760 (1277228) 1277228..1277974 - 747 WP_000788740.1 ATP-binding protein -
C1P89_RS06765 (1277981) 1277981..1279045 - 1065 WP_001262380.1 hypothetical protein -
C1P89_RS06770 (1279117) 1279117..1279542 - 426 WP_000693826.1 toxin YdaT family protein -
C1P89_RS06775 (1279539) 1279539..1279802 - 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
C1P89_RS06780 (1279929) 1279929..1280414 + 486 WP_053002468.1 helix-turn-helix domain-containing protein -
C1P89_RS06785 (1280434) 1280434..1280628 + 195 WP_005142544.1 hypothetical protein Antitoxin
C1P89_RS06790 (1280628) 1280628..1280918 + 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1P89_RS06795 (1281198) 1281198..1281350 + 153 WP_000379558.1 DUF1391 family protein -
C1P89_RS06800 (1281362) 1281362..1281727 + 366 WP_024174355.1 hypothetical protein -
C1P89_RS06815 (1283105) 1283105..1283894 + 790 Protein_1292 Rha family transcriptional regulator -
C1P89_RS06825 (1284642) 1284642..1284737 + 96 Protein_1294 transcriptional regulator -
C1P89_RS06830 (1284748) 1284748..1284936 + 189 WP_000449206.1 cell division inhibition protein DicB -
C1P89_RS06835 (1284933) 1284933..1285124 + 192 WP_001090204.1 DUF1482 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vgrG/tssI / rhs/PAAR / rhs/PAAR / sodB 1145721..1381582 235861


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T96037 WP_014334020.1 NZ_CP026802:1280628-1280918 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T96037 NZ_CP026802:1280628-1280918 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT96037 WP_005142544.1 NZ_CP026802:1280434-1280628 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT96037 NZ_CP026802:1280434-1280628 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References