Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 326582..327236 Replicon chromosome
Accession NZ_CP026795
Organism Shigella boydii strain ATCC BAA-1247

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag C5B80_RS01760 Protein ID WP_000244777.1
Coordinates 326829..327236 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C5B80_RS01755 Protein ID WP_000354046.1
Coordinates 326582..326848 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B80_RS01730 321751..322494 + 744 WP_000951947.1 SDR family oxidoreductase -
C5B80_RS01735 322551..323984 - 1434 WP_141095395.1 6-phospho-beta-glucosidase BglA -
C5B80_RS01740 324029..324340 + 312 WP_001182969.1 N(4)-acetylcytidine aminohydrolase -
C5B80_RS01745 324504..325163 + 660 WP_000250274.1 hemolysin III family protein -
C5B80_RS01750 325359..326339 - 981 WP_000886098.1 tRNA-modifying protein YgfZ -
C5B80_RS01755 326582..326848 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C5B80_RS01760 326829..327236 + 408 WP_000244777.1 toxin CptA Toxin
C5B80_RS01765 327276..327797 - 522 WP_001055874.1 flavodoxin FldB -
C5B80_RS01770 327909..328805 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
C5B80_RS01775 328830..329540 + 711 WP_000715205.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C5B80_RS01780 329546..331279 + 1734 WP_000813182.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T95996 WP_000244777.1 NZ_CP026795:326829-327236 [Shigella boydii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T95996 NZ_CP026795:326829-327236 [Shigella boydii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGATTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT95996 WP_000354046.1 NZ_CP026795:326582-326848 [Shigella boydii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT95996 NZ_CP026795:326582-326848 [Shigella boydii]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References