Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 881295..881949 Replicon chromosome
Accession NZ_CP026793
Organism Shigella flexneri strain 74-1170

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag C1P81_RS04305 Protein ID WP_000244767.1
Coordinates 881295..881702 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag C1P81_RS04310 Protein ID WP_000354044.1
Coordinates 881683..881949 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P81_RS04285 (877252) 877252..878985 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
C1P81_RS04290 (878991) 878991..879701 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P81_RS04295 (879726) 879726..880622 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
C1P81_RS04300 (880734) 880734..881255 + 522 WP_001055867.1 flavodoxin FldB -
C1P81_RS04305 (881295) 881295..881702 - 408 WP_000244767.1 protein YgfX Toxin
C1P81_RS04310 (881683) 881683..881949 - 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
C1P81_RS04315 (882192) 882192..883172 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
C1P81_RS04320 (883368) 883368..884027 - 660 WP_000250274.1 hemolysin III family protein -
C1P81_RS04325 (884191) 884191..884501 - 311 Protein_825 N(4)-acetylcytidine aminohydrolase -
C1P81_RS04330 (884546) 884546..885979 + 1434 WP_005051722.1 6-phospho-beta-glucosidase BglA -
C1P81_RS04335 (886036) 886036..886779 - 744 WP_000951957.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T95969 WP_000244767.1 NZ_CP026793:c881702-881295 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T95969 NZ_CP026793:c881702-881295 [Shigella flexneri]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT95969 WP_000354044.1 NZ_CP026793:c881949-881683 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT95969 NZ_CP026793:c881949-881683 [Shigella flexneri]
ATGGACATTAACAACAAAGCCCGAATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References