Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1138683..1139337 Replicon chromosome
Accession NZ_CP026792
Organism Shigella flexneri strain 61-4982

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag C1P80_RS06070 Protein ID WP_000244767.1
Coordinates 1138930..1139337 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag C1P80_RS06065 Protein ID WP_000354044.1
Coordinates 1138683..1138949 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P80_RS06040 1133853..1134596 + 744 WP_000951957.1 SDR family oxidoreductase -
C1P80_RS06045 1134653..1136086 - 1434 WP_005076748.1 6-phospho-beta-glucosidase BglA -
C1P80_RS06050 1136131..1136441 + 311 Protein_1083 ASCH domain-containing protein -
C1P80_RS06055 1136605..1137264 + 660 WP_000250274.1 hemolysin III family protein -
C1P80_RS06060 1137460..1138440 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
C1P80_RS06065 1138683..1138949 + 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
C1P80_RS06070 1138930..1139337 + 408 WP_000244767.1 protein YgfX Toxin
C1P80_RS06075 1139377..1139898 - 522 WP_001055867.1 flavodoxin FldB -
C1P80_RS06080 1140010..1140906 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
C1P80_RS06085 1140931..1141641 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P80_RS06090 1141647..1143380 + 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T95959 WP_000244767.1 NZ_CP026792:1138930-1139337 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T95959 NZ_CP026792:1138930-1139337 [Shigella flexneri]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT95959 WP_000354044.1 NZ_CP026792:1138683-1138949 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT95959 NZ_CP026792:1138683-1138949 [Shigella flexneri]
ATGGACATTAACAACAAAGCCCGAATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References