Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 99194..99825 Replicon chromosome
Accession NZ_CP026792
Organism Shigella flexneri strain 61-4982

Toxin (Protein)


Gene name hicA Uniprot ID A0A822PMR8
Locus tag C1P80_RS00860 Protein ID WP_001259384.1
Coordinates 99194..99469 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag C1P80_RS00865 Protein ID WP_000593555.1
Coordinates 99466..99825 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P80_RS00845 94212..95279 + 1068 WP_000361470.1 HlyD family secretion protein -
C1P80_RS00850 95276..98011 + 2736 WP_000149173.1 ribosome-associated ATPase/putative transporter RbbA -
C1P80_RS00855 98011..99135 + 1125 WP_001216257.1 ABC transporter permease -
C1P80_RS00860 99194..99469 + 276 WP_001259384.1 type II toxin-antitoxin system HicA family toxin Toxin
C1P80_RS00865 99466..99825 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C1P80_RS00870 99945..100346 - 402 WP_001190069.1 nickel-responsive transcriptional regulator NikR -
C1P80_RS00875 100352..101158 - 807 WP_000173660.1 nickel import ATP-binding protein NikE -
C1P80_RS00880 101155..101919 - 765 WP_001136248.1 nickel import ATP-binding protein NikD -
C1P80_RS00885 101919..102752 - 834 WP_001008974.1 nickel ABC transporter permease subunit NikC -
C1P80_RS00890 102749..103693 - 945 WP_000947076.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-81)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10146.89 Da        Isoelectric Point: 10.3748

>T95957 WP_001259384.1 NZ_CP026792:99194-99469 [Shigella flexneri]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
CDWLLSIGVKP

Download         Length: 276 bp

>T95957 NZ_CP026792:99194-99469 [Shigella flexneri]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
TGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT95957 WP_000593555.1 NZ_CP026792:99466-99825 [Shigella flexneri]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT95957 NZ_CP026792:99466-99825 [Shigella flexneri]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGAG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822PMR8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References