Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3975132..3975786 Replicon chromosome
Accession NZ_CP026788
Organism Shigella flexneri 2a strain ATCC 29903

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag C1P79_RS20475 Protein ID WP_000244767.1
Coordinates 3975379..3975786 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag C1P79_RS20470 Protein ID WP_000354044.1
Coordinates 3975132..3975398 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P79_RS20445 (3970302) 3970302..3971045 + 744 WP_000951957.1 SDR family oxidoreductase -
C1P79_RS20450 (3971102) 3971102..3972535 - 1434 WP_005051722.1 6-phospho-beta-glucosidase BglA -
C1P79_RS20455 (3972580) 3972580..3972890 + 311 Protein_3909 N(4)-acetylcytidine aminohydrolase -
C1P79_RS20460 (3973054) 3973054..3973713 + 660 WP_000250274.1 hemolysin III family protein -
C1P79_RS20465 (3973909) 3973909..3974889 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
C1P79_RS20470 (3975132) 3975132..3975398 + 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
C1P79_RS20475 (3975379) 3975379..3975786 + 408 WP_000244767.1 protein YgfX Toxin
C1P79_RS20480 (3975826) 3975826..3976347 - 522 WP_001055867.1 flavodoxin FldB -
C1P79_RS20485 (3976459) 3976459..3977355 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
C1P79_RS20490 (3977380) 3977380..3978090 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P79_RS20495 (3978096) 3978096..3979829 + 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T95950 WP_000244767.1 NZ_CP026788:3975379-3975786 [Shigella flexneri 2a]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T95950 NZ_CP026788:3975379-3975786 [Shigella flexneri 2a]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT95950 WP_000354044.1 NZ_CP026788:3975132-3975398 [Shigella flexneri 2a]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT95950 NZ_CP026788:3975132-3975398 [Shigella flexneri 2a]
ATGGACATTAACAACAAAGCCCGAATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References