Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 55949..56474 | Replicon | plasmid unnamed |
| Accession | NZ_CP026787 | ||
| Organism | Shigella dysenteriae strain NCTC 9718 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | Q326Z8 |
| Locus tag | C1P65_RS24295 | Protein ID | WP_001159860.1 |
| Coordinates | 56169..56474 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | Q7BEK0 |
| Locus tag | C1P65_RS24290 | Protein ID | WP_000813626.1 |
| Coordinates | 55949..56167 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C1P65_RS24260 | 51686..51970 | + | 285 | WP_001178088.1 | ribbon-helix-helix domain-containing protein | - |
| C1P65_RS24265 | 51970..52245 | + | 276 | WP_000421263.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| C1P65_RS26400 | 52377..52514 | - | 138 | WP_000766699.1 | hypothetical protein | - |
| C1P65_RS24270 | 52606..52971 | - | 366 | WP_000361390.1 | plasmid partitioning/stability family protein | - |
| C1P65_RS24275 | 52974..53542 | - | 569 | Protein_69 | plasmid segregation protein ParM | - |
| C1P65_RS24280 | 53550..54640 | + | 1091 | Protein_70 | IS66 family transposase | - |
| C1P65_RS24285 | 55016..55709 | - | 694 | Protein_71 | IS1 family transposase | - |
| C1P65_RS24290 | 55949..56167 | + | 219 | WP_000813626.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| C1P65_RS24295 | 56169..56474 | + | 306 | WP_001159860.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| C1P65_RS24300 | 56510..56605 | + | 96 | Protein_74 | transposase domain-containing protein | - |
| C1P65_RS24305 | 56733..57427 | + | 695 | WP_087786203.1 | IS1-like element IS1N family transposase | - |
| C1P65_RS24310 | 57641..59278 | + | 1638 | WP_000936810.1 | T3SS effector E3 ubiquitin-protein ligase IpaH9.8 | - |
| C1P65_RS24315 | 59486..59755 | + | 270 | WP_000079957.1 | hypothetical protein | - |
| C1P65_RS26585 | 59752..59978 | + | 227 | Protein_78 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| C1P65_RS24325 | 60007..60597 | + | 591 | WP_000705601.1 | type III secretion system effector protein kinase OspG | - |
| C1P65_RS26405 | 60936..61220 | + | 285 | Protein_80 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | nleE / icsP/sopA / ospB / ospC2 / ospD2 / ospF / ospD1 / ipgB2 / ipaH4.5 / ipaH7.8 / ospI / ipaH9.8 / ospG / espC / ipaH2.5 / ipaH2.5 / ospE2 / espC / ospC3 / ipaJ / ipaA / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / spa40 / virA / virA / icsA/virG / nleE / icsP/sopA / ospB / ospC4 / ospC2 / ospD2 / ospD2 / ospD2 | 1..189871 | 189871 | |
| - | inside | IScluster/Tn | - | ospI / ipaH9.8 / ospG | 45223..62629 | 17406 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11736.59 Da Isoelectric Point: 6.4674
>T95928 WP_001159860.1 NZ_CP026787:56169-56474 [Shigella dysenteriae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T95928 NZ_CP026787:56169-56474 [Shigella dysenteriae]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGACGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACTGATATGGCCAGTGTGCCGATCTTCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGACGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACTGATATGGCCAGTGTGCCGATCTTCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8333.36 Da Isoelectric Point: 6.2838
>AT95928 WP_000813626.1 NZ_CP026787:55949-56167 [Shigella dysenteriae]
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW
Download Length: 219 bp
>AT95928 NZ_CP026787:55949-56167 [Shigella dysenteriae]
ATGAAGCAGCGTATTACTGTCACTATAGACAGTGACAGCTATCAGTTACTTAAATCCGCAAACGTGAATATCTCAGGCCT
GGTAAATACGGCCATGCAAAAAGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCTGAAAATCAGCAGGGGATGGCTG
AGATCGCCCGTTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA
ATGAAGCAGCGTATTACTGTCACTATAGACAGTGACAGCTATCAGTTACTTAAATCCGCAAACGTGAATATCTCAGGCCT
GGTAAATACGGCCATGCAAAAAGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCTGAAAATCAGCAGGGGATGGCTG
AGATCGCCCGTTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4P7TTN3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7BEK0 |