Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2637208..2637962 Replicon chromosome
Accession NZ_CP026786
Organism Shigella dysenteriae strain NCTC 9718

Toxin (Protein)


Gene name ataT Uniprot ID Q32AN3
Locus tag C1P65_RS14480 Protein ID WP_000513068.1
Coordinates 2637477..2637962 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A2X2KZA0
Locus tag C1P65_RS14475 Protein ID WP_000801913.1
Coordinates 2637208..2637486 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P65_RS14470 2634442..2637141 + 2700 WP_000907049.1 HTH-type transcriptional regulator MalT -
C1P65_RS14475 2637208..2637486 + 279 WP_000801913.1 DUF1778 domain-containing protein Antitoxin
C1P65_RS14480 2637477..2637962 + 486 WP_000513068.1 GNAT family N-acetyltransferase Toxin
C1P65_RS14485 2638012..2639040 - 1029 WP_024259430.1 RNA 3'-terminal phosphate cyclase -
C1P65_RS14490 2639044..2639544 - 501 Protein_2685 RNA-splicing ligase RtcB -
C1P65_RS14495 2639544..2640053 + 510 Protein_2686 DNA-binding transcriptional regulator RtcR -
C1P65_RS14500 2640035..2640793 - 759 WP_000815099.1 DeoR/GlpR family transcriptional regulator -
C1P65_RS14505 2640810..2641640 - 831 WP_000928722.1 rhomboid family intramembrane serine protease GlpG -
C1P65_RS14510 2641685..2642011 - 327 WP_000371932.1 thiosulfate sulfurtransferase GlpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17631.53 Da        Isoelectric Point: 9.1197

>T95923 WP_000513068.1 NZ_CP026786:2637477-2637962 [Shigella dysenteriae]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRHNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

>T95923 NZ_CP026786:2637477-2637962 [Shigella dysenteriae]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCATTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACATAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10449.00 Da        Isoelectric Point: 4.6336

>AT95923 WP_000801913.1 NZ_CP026786:2637208-2637486 [Shigella dysenteriae]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQVK
INALMNRKSPWE

Download         Length: 279 bp

>AT95923 NZ_CP026786:2637208-2637486 [Shigella dysenteriae]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGTCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090ND96

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2KZA0

References