Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 698987..699785 Replicon chromosome
Accession NZ_CP026786
Organism Shigella dysenteriae strain NCTC 9718

Toxin (Protein)


Gene name yeeV Uniprot ID Q32HN1
Locus tag C1P65_RS04165 Protein ID WP_001094433.1
Coordinates 699411..699785 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q32HN0
Locus tag C1P65_RS04160 Protein ID WP_001285603.1
Coordinates 698987..699364 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P65_RS04110 694167..694634 + 468 WP_000668907.1 hypothetical protein -
C1P65_RS04115 695065..695548 + 484 Protein_764 hypothetical protein -
C1P65_RS04120 695668..695841 + 174 WP_000088742.1 DUF905 family protein -
C1P65_RS04130 695942..696763 + 822 WP_001234573.1 DUF945 domain-containing protein -
C1P65_RS04140 697043..697516 + 474 WP_001313575.1 antirestriction protein -
C1P65_RS04145 697532..697984 + 453 WP_001186198.1 RadC family protein -
C1P65_RS04150 698053..698274 + 222 WP_000692331.1 DUF987 domain-containing protein -
C1P65_RS04155 698293..698937 + 645 WP_000086764.1 hypothetical protein -
C1P65_RS04160 698987..699364 + 378 WP_001285603.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C1P65_RS04165 699411..699785 + 375 WP_001094433.1 toxin Toxin
C1P65_RS04170 699782..700273 + 492 WP_000976859.1 hypothetical protein -
C1P65_RS04175 700285..700482 + 198 WP_000839257.1 DUF957 domain-containing protein -
C1P65_RS04180 700579..701421 + 843 WP_005020348.1 DUF4942 domain-containing protein -
C1P65_RS04190 701891..702829 + 939 WP_000351336.1 glyoxylate/hydroxypyruvate reductase GhrA -
C1P65_RS04195 702884..703621 + 738 WP_000283663.1 zinc-binding phosphatase -
C1P65_RS04200 703645..704199 + 555 WP_001001927.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13918.86 Da        Isoelectric Point: 6.8517

>T95918 WP_001094433.1 NZ_CP026786:699411-699785 [Shigella dysenteriae]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSPLINSIDILRARRVTGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T95918 NZ_CP026786:699411-699785 [Shigella dysenteriae]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCCGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGTGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13789.72 Da        Isoelectric Point: 6.4643

>AT95918 WP_001285603.1 NZ_CP026786:698987-699364 [Shigella dysenteriae]
VSDTLPGTTLPDDNKDRPWWRLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT95918 NZ_CP026786:698987-699364 [Shigella dysenteriae]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGATAACAAAGACCGCCCCTGGTGGAGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NBY3

Antitoxin

Source ID Structure
AlphaFold DB A0A090NW75

References