Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3301858..3302656 Replicon chromosome
Accession NZ_CP026784
Organism Shigella dysenteriae strain 80-547

Toxin (Protein)


Gene name yeeV Uniprot ID Q32HN1
Locus tag C5B79_RS18205 Protein ID WP_001094433.1
Coordinates 3302282..3302656 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q32HN0
Locus tag C5B79_RS18200 Protein ID WP_001285603.1
Coordinates 3301858..3302235 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B79_RS18150 3297038..3297505 + 468 WP_000668907.1 hypothetical protein -
C5B79_RS18155 3297936..3298419 + 484 Protein_3381 hypothetical protein -
C5B79_RS18160 3298539..3298712 + 174 WP_000088742.1 DUF905 family protein -
C5B79_RS18170 3298813..3299634 + 822 WP_001234573.1 DUF945 domain-containing protein -
C5B79_RS18180 3299914..3300387 + 474 WP_001313575.1 antirestriction protein -
C5B79_RS18185 3300403..3300855 + 453 WP_001186198.1 RadC family protein -
C5B79_RS18190 3300924..3301145 + 222 WP_000692331.1 DUF987 domain-containing protein -
C5B79_RS18195 3301164..3301808 + 645 WP_000086764.1 hypothetical protein -
C5B79_RS18200 3301858..3302235 + 378 WP_001285603.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C5B79_RS18205 3302282..3302656 + 375 WP_001094433.1 toxin Toxin
C5B79_RS18210 3302653..3303144 + 492 WP_000976859.1 hypothetical protein -
C5B79_RS18215 3303156..3303353 + 198 WP_000839257.1 DUF957 domain-containing protein -
C5B79_RS18220 3303450..3304292 + 843 WP_005020348.1 DUF4942 domain-containing protein -
C5B79_RS18230 3304764..3305702 + 939 WP_000351336.1 glyoxylate/hydroxypyruvate reductase GhrA -
C5B79_RS18235 3305757..3306494 + 738 WP_000283663.1 zinc-binding phosphatase -
C5B79_RS18240 3306518..3307072 + 555 WP_001001927.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 / ipaH9.8 / rcsA / iroB / iroC / iroD / iroE / iroN / csgG / csgF / csgE / csgD 3238190..3319776 81586


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13918.86 Da        Isoelectric Point: 6.8517

>T95902 WP_001094433.1 NZ_CP026784:3302282-3302656 [Shigella dysenteriae]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSPLINSIDILRARRVTGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T95902 NZ_CP026784:3302282-3302656 [Shigella dysenteriae]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCCGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGTGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13789.72 Da        Isoelectric Point: 6.4643

>AT95902 WP_001285603.1 NZ_CP026784:3301858-3302235 [Shigella dysenteriae]
VSDTLPGTTLPDDNKDRPWWRLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT95902 NZ_CP026784:3301858-3302235 [Shigella dysenteriae]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGATAACAAAGACCGCCCCTGGTGGAGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NBY3

Antitoxin

Source ID Structure
AlphaFold DB A0A090NW75

References