Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1300168..1300822 Replicon chromosome
Accession NZ_CP026784
Organism Shigella dysenteriae strain 80-547

Toxin (Protein)


Gene name cptA Uniprot ID Q32BV9
Locus tag C5B79_RS07060 Protein ID WP_000244779.1
Coordinates 1300168..1300575 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C5B79_RS07065 Protein ID WP_000354046.1
Coordinates 1300556..1300822 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B79_RS07040 1296125..1297858 - 1734 WP_000813170.1 single-stranded-DNA-specific exonuclease RecJ -
C5B79_RS07045 1297864..1298574 - 711 WP_134806394.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C5B79_RS07050 1298599..1299495 - 897 WP_078232661.1 site-specific tyrosine recombinase XerD -
C5B79_RS07055 1299607..1300128 + 522 WP_001055874.1 flavodoxin FldB -
C5B79_RS07060 1300168..1300575 - 408 WP_000244779.1 protein YgfX Toxin
C5B79_RS07065 1300556..1300822 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C5B79_RS07070 1301065..1302045 + 981 WP_000886092.1 tRNA-modifying protein YgfZ -
C5B79_RS07075 1302122..1302718 - 597 Protein_1304 hemolysin III family protein -
C5B79_RS07080 1302776..1303470 + 695 WP_087786203.1 IS1-like element IS1N family transposase -
C5B79_RS07085 1303719..1304030 - 312 WP_134802107.1 N(4)-acetylcytidine aminohydrolase -
C5B79_RS07090 1304075..1305508 + 1434 Protein_1307 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1303075..1303470 395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.2669

>T95891 WP_000244779.1 NZ_CP026784:c1300575-1300168 [Shigella dysenteriae]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRWILLQQETQR

Download         Length: 408 bp

>T95891 NZ_CP026784:c1300575-1300168 [Shigella dysenteriae]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGTGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT95891 WP_000354046.1 NZ_CP026784:c1300822-1300556 [Shigella dysenteriae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT95891 NZ_CP026784:c1300822-1300556 [Shigella dysenteriae]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NWM4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References