Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 53650..54175 | Replicon | plasmid unnamed |
| Accession | NZ_CP026783 | ||
| Organism | Shigella dysenteriae strain 08-3380 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | Q326Z8 |
| Locus tag | C1P64_RS25610 | Protein ID | WP_001159860.1 |
| Coordinates | 53650..53955 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | Q7BEK0 |
| Locus tag | C1P64_RS25615 | Protein ID | WP_000813626.1 |
| Coordinates | 53957..54175 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C1P64_RS26900 | 48903..49187 | - | 285 | Protein_54 | IS66 family insertion sequence element accessory protein TnpB | - |
| C1P64_RS25575 | 49526..50116 | - | 591 | WP_000705601.1 | type III secretion system effector protein kinase OspG | - |
| C1P64_RS27120 | 50145..50371 | - | 227 | Protein_56 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| C1P64_RS25585 | 50368..50637 | - | 270 | WP_000079957.1 | hypothetical protein | - |
| C1P64_RS25590 | 50845..52483 | - | 1639 | Protein_58 | T3SS effector E3 ubiquitin-protein ligase IpaH9.8 | - |
| C1P64_RS25605 | 53519..53614 | - | 96 | Protein_60 | transposase domain-containing protein | - |
| C1P64_RS25610 | 53650..53955 | - | 306 | WP_001159860.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| C1P64_RS25615 | 53957..54175 | - | 219 | WP_000813626.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| C1P64_RS25625 | 54415..55108 | + | 694 | Protein_63 | IS1 family transposase | - |
| C1P64_RS25630 | 55484..56574 | - | 1091 | Protein_64 | IS66 family transposase | - |
| C1P64_RS25635 | 56582..57150 | + | 569 | Protein_65 | plasmid segregation protein ParM | - |
| C1P64_RS25640 | 57153..57518 | + | 366 | WP_000361390.1 | plasmid partitioning/stability family protein | - |
| C1P64_RS26905 | 57610..57747 | + | 138 | WP_000766699.1 | hypothetical protein | - |
| C1P64_RS25645 | 57879..58154 | - | 276 | WP_000421263.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| C1P64_RS25650 | 58154..58438 | - | 285 | WP_001178088.1 | ribbon-helix-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ipaJ / ospC3 / ospG / ipaH9.8 / ipaH9.8 / ospI / ospC2 / ospD3/senA / ospC1 / ospE2 / ipaH1.4 / ipaH7.8 / ipaH4.5 / ipgB2 / ospD1 / ospF / ospD2 / ospC2 / ospB / icsP/sopA / nleE / icsA/virG / virA / spa40 / spa29 / spa9 / spa24 / spa33 / spa32 / spa13 / spa47 / spa15 / mxiA / mxiC / mxiD / mxiE / mxiM / mxiL / mxiN / mxiK / mxiJ / mxiI / mxiH / mxiG / ipgF / ipgE / ipgD / icsB / ipgA / ipgB1 / ipgC / ipaB / ipaC / ipaD / ipaA | 1..183210 | 183210 | |
| - | inside | IScluster/Tn | - | ospG / ipaH9.8 / ipaH9.8 / ospI / ospC2 / ospD3/senA / ospC1 / ospE2 / ipaH1.4 | 47494..92057 | 44563 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11736.59 Da Isoelectric Point: 6.4674
>T95887 WP_001159860.1 NZ_CP026783:c53955-53650 [Shigella dysenteriae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T95887 NZ_CP026783:c53955-53650 [Shigella dysenteriae]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGACGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACTGATATGGCCAGTGTGCCGATCTTCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGACGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACTGATATGGCCAGTGTGCCGATCTTCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8333.36 Da Isoelectric Point: 6.2838
>AT95887 WP_000813626.1 NZ_CP026783:c54175-53957 [Shigella dysenteriae]
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW
Download Length: 219 bp
>AT95887 NZ_CP026783:c54175-53957 [Shigella dysenteriae]
ATGAAGCAGCGTATTACTGTCACTATAGACAGTGACAGCTATCAGTTACTTAAATCCGCAAACGTGAATATCTCAGGCCT
GGTAAATACGGCCATGCAAAAAGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCTGAAAATCAGCAGGGGATGGCTG
AGATCGCCCGTTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA
ATGAAGCAGCGTATTACTGTCACTATAGACAGTGACAGCTATCAGTTACTTAAATCCGCAAACGTGAATATCTCAGGCCT
GGTAAATACGGCCATGCAAAAAGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCTGAAAATCAGCAGGGGATGGCTG
AGATCGCCCGTTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4P7TTN3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7BEK0 |