Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3150459..3151257 Replicon chromosome
Accession NZ_CP026782
Organism Shigella dysenteriae strain 08-3380

Toxin (Protein)


Gene name yeeV Uniprot ID Q32HN1
Locus tag C1P64_RS17395 Protein ID WP_001094433.1
Coordinates 3150459..3150833 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q32HN0
Locus tag C1P64_RS17400 Protein ID WP_001285603.1
Coordinates 3150880..3151257 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P64_RS17360 3146044..3146598 - 555 WP_001001927.1 molecular chaperone YcdY -
C1P64_RS17365 3146622..3147359 - 738 WP_000283663.1 zinc-binding phosphatase -
C1P64_RS17370 3147414..3148352 - 939 WP_000351336.1 glyoxylate/hydroxypyruvate reductase GhrA -
C1P64_RS17380 3148823..3149665 - 843 WP_005020348.1 DUF4942 domain-containing protein -
C1P64_RS17385 3149762..3149959 - 198 WP_000839257.1 DUF957 domain-containing protein -
C1P64_RS17390 3149971..3150462 - 492 WP_000976859.1 hypothetical protein -
C1P64_RS17395 3150459..3150833 - 375 WP_001094433.1 toxin Toxin
C1P64_RS17400 3150880..3151257 - 378 WP_001285603.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C1P64_RS17405 3151307..3151951 - 645 WP_000086764.1 hypothetical protein -
C1P64_RS17410 3151970..3152191 - 222 WP_000692331.1 DUF987 domain-containing protein -
C1P64_RS17415 3152260..3152712 - 453 WP_001186198.1 RadC family protein -
C1P64_RS17420 3152728..3153201 - 474 WP_001313575.1 antirestriction protein -
C1P64_RS17430 3153481..3154302 - 822 WP_001234573.1 DUF945 domain-containing protein -
C1P64_RS17440 3154403..3154576 - 174 WP_000088742.1 DUF905 family protein -
C1P64_RS17445 3154696..3155179 - 484 Protein_3179 hypothetical protein -
C1P64_RS17450 3155610..3156077 - 468 WP_000668907.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13918.86 Da        Isoelectric Point: 6.8517

>T95874 WP_001094433.1 NZ_CP026782:c3150833-3150459 [Shigella dysenteriae]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSPLINSIDILRARRVTGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T95874 NZ_CP026782:c3150833-3150459 [Shigella dysenteriae]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCCGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGTGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13789.72 Da        Isoelectric Point: 6.4643

>AT95874 WP_001285603.1 NZ_CP026782:c3151257-3150880 [Shigella dysenteriae]
VSDTLPGTTLPDDNKDRPWWRLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT95874 NZ_CP026782:c3151257-3150880 [Shigella dysenteriae]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGATAACAAAGACCGCCCCTGGTGGAGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NBY3

Antitoxin

Source ID Structure
AlphaFold DB A0A090NW75

References