Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 742159..742813 Replicon chromosome
Accession NZ_CP026782
Organism Shigella dysenteriae strain 08-3380

Toxin (Protein)


Gene name cptA Uniprot ID Q32BV9
Locus tag C1P64_RS04055 Protein ID WP_000244779.1
Coordinates 742406..742813 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C1P64_RS04050 Protein ID WP_000354046.1
Coordinates 742159..742425 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P64_RS04025 737473..738906 - 1434 Protein_746 6-phospho-beta-glucosidase BglA -
C1P64_RS04030 738951..739262 + 312 WP_134802107.1 N(4)-acetylcytidine aminohydrolase -
C1P64_RS04040 740263..740859 + 597 Protein_749 hemolysin III family protein -
C1P64_RS04045 740936..741916 - 981 WP_000886092.1 tRNA-modifying protein YgfZ -
C1P64_RS04050 742159..742425 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C1P64_RS04055 742406..742813 + 408 WP_000244779.1 protein YgfX Toxin
C1P64_RS04060 742853..743374 - 522 WP_001055874.1 flavodoxin FldB -
C1P64_RS04065 743486..744382 + 897 WP_078232661.1 site-specific tyrosine recombinase XerD -
C1P64_RS04070 744407..745117 + 711 WP_000715209.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P64_RS04075 745123..746856 + 1734 WP_000813170.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 739511..739906 395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.2669

>T95868 WP_000244779.1 NZ_CP026782:742406-742813 [Shigella dysenteriae]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRWILLQQETQR

Download         Length: 408 bp

>T95868 NZ_CP026782:742406-742813 [Shigella dysenteriae]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGTGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT95868 WP_000354046.1 NZ_CP026782:742159-742425 [Shigella dysenteriae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT95868 NZ_CP026782:742159-742425 [Shigella dysenteriae]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NWM4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References