Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4030430..4031025 Replicon chromosome
Accession NZ_CP026780
Organism Shigella dysenteriae strain 53-3937

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag C1P63_RS22080 Protein ID WP_000239577.1
Coordinates 4030675..4031025 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2X2I2M3
Locus tag C1P63_RS22075 Protein ID WP_001223211.1
Coordinates 4030430..4030681 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P63_RS22065 4026095..4029874 + 3780 WP_000060952.1 autotransporter assembly complex protein TamB -
C1P63_RS22070 4029877..4030218 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
C1P63_RS22075 4030430..4030681 + 252 WP_001223211.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
C1P63_RS22080 4030675..4031025 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
C1P63_RS22085 4031102..4031632 - 531 WP_000055075.1 inorganic diphosphatase -
C1P63_RS22090 4031942..4032442 + 501 Protein_4111 galactofuranose ABC transporter substrate-binding protein YtfQ -
C1P63_RS22100 4033209..4034294 + 1086 Protein_4113 cadaverine/lysine antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - htpB 4005369..4066838 61469


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T95863 WP_000239577.1 NZ_CP026780:4030675-4031025 [Shigella dysenteriae]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T95863 NZ_CP026780:4030675-4031025 [Shigella dysenteriae]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTTGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9315.64 Da        Isoelectric Point: 4.4201

>AT95863 WP_001223211.1 NZ_CP026780:4030430-4030681 [Shigella dysenteriae]
MRITIKRWGNSAGMVIPNVVMKELNLWPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT95863 NZ_CP026780:4030430-4030681 [Shigella dysenteriae]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTATG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGTTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCTACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2I2M3

References