Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4030430..4031025 Replicon chromosome
Accession NZ_CP026780
Organism Shigella dysenteriae strain 53-3937

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag C1P63_RS22080 Protein ID WP_000239577.1
Coordinates 4030675..4031025 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2X2I2M3
Locus tag C1P63_RS22075 Protein ID WP_001223211.1
Coordinates 4030430..4030681 (+) Length 84 a.a.

Genomic Context


C1P63_RS22065C1P63_RS22070C1P63_RS22075C1P63_RS22080C1P63_RS22090C1P63_RS22100C1P63_RS22085
Location: 4026095..4029874 (3780 bp)
Type: Others
Protein ID: WP_000060952.1
Location: 4029877..4030218 (342 bp)
Type: Others
Protein ID: WP_001219160.1
Location: 4030430..4030681 (252 bp)
Type: Antitoxin
Protein ID: WP_001223211.1
Location: 4030675..4031025 (351 bp)
Type: Toxin
Protein ID: WP_000239577.1
Location: 4031942..4032442 (501 bp)
Type: Others
Protein ID: Protein_4111
Location: 4033209..4034294 (1086 bp)
Type: Others
Protein ID: Protein_4113
Location: 4031102..4031632 (531 bp)
Type: Others
Protein ID: WP_000055075.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1P63_RS220654026095..4029874+3780WP_000060952.1autotransporter assembly complex protein TamB-
C1P63_RS220704029877..4030218+342WP_001219160.1gamma-glutamylcyclotransferase-
C1P63_RS220754030430..4030681+252WP_001223211.1type II toxin-antitoxin system antitoxin ChpSAntitoxin
C1P63_RS220804030675..4031025+351WP_000239577.1endoribonuclease toxin ChpBToxin
C1P63_RS220854031102..4031632-531WP_000055075.1inorganic diphosphatase-
C1P63_RS220904031942..4032442+501Protein_4111galactofuranose ABC transporter substrate-binding protein YtfQ-
C1P63_RS221004033209..4034294+1086Protein_4113cadaverine/lysine antiporter-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage-htpB4005369..406683861469


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-114)

Antitoxin

(1-83)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T95863 WP_000239577.1 NZ_CP026780:4030675-4031025 [Shigella dysenteriae]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T95863 NZ_CP026780:4030675-4031025 [Shigella dysenteriae]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTTGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9315.64 Da        Isoelectric Point: 4.4201

>AT95863 WP_001223211.1 NZ_CP026780:4030430-4030681 [Shigella dysenteriae]
MRITIKRWGNSAGMVIPNVVMKELNLWPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT95863 NZ_CP026780:4030430-4030681 [Shigella dysenteriae]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTATG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGTTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCTACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBU9XNP6


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2X2I2M3

References