Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | chpSB/PRK09812-ChpS |
Location | 4030430..4031025 | Replicon | chromosome |
Accession | NZ_CP026780 | ||
Organism | Shigella dysenteriae strain 53-3937 |
Toxin (Protein)
Gene name | chpB | Uniprot ID | U9XNP6 |
Locus tag | C1P63_RS22080 | Protein ID | WP_000239577.1 |
Coordinates | 4030675..4031025 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | chpS | Uniprot ID | A0A2X2I2M3 |
Locus tag | C1P63_RS22075 | Protein ID | WP_001223211.1 |
Coordinates | 4030430..4030681 (+) | Length | 84 a.a. |
Genomic Context
Location: 4026095..4029874 (3780 bp)
Type: Others
Protein ID: WP_000060952.1
Type: Others
Protein ID: WP_000060952.1
Location: 4029877..4030218 (342 bp)
Type: Others
Protein ID: WP_001219160.1
Type: Others
Protein ID: WP_001219160.1
Location: 4030430..4030681 (252 bp)
Type: Antitoxin
Protein ID: WP_001223211.1
Type: Antitoxin
Protein ID: WP_001223211.1
Location: 4030675..4031025 (351 bp)
Type: Toxin
Protein ID: WP_000239577.1
Type: Toxin
Protein ID: WP_000239577.1
Location: 4031942..4032442 (501 bp)
Type: Others
Protein ID: Protein_4111
Type: Others
Protein ID: Protein_4111
Location: 4033209..4034294 (1086 bp)
Type: Others
Protein ID: Protein_4113
Type: Others
Protein ID: Protein_4113
Location: 4031102..4031632 (531 bp)
Type: Others
Protein ID: WP_000055075.1
Type: Others
Protein ID: WP_000055075.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C1P63_RS22065 | 4026095..4029874 | + | 3780 | WP_000060952.1 | autotransporter assembly complex protein TamB | - |
C1P63_RS22070 | 4029877..4030218 | + | 342 | WP_001219160.1 | gamma-glutamylcyclotransferase | - |
C1P63_RS22075 | 4030430..4030681 | + | 252 | WP_001223211.1 | type II toxin-antitoxin system antitoxin ChpS | Antitoxin |
C1P63_RS22080 | 4030675..4031025 | + | 351 | WP_000239577.1 | endoribonuclease toxin ChpB | Toxin |
C1P63_RS22085 | 4031102..4031632 | - | 531 | WP_000055075.1 | inorganic diphosphatase | - |
C1P63_RS22090 | 4031942..4032442 | + | 501 | Protein_4111 | galactofuranose ABC transporter substrate-binding protein YtfQ | - |
C1P63_RS22100 | 4033209..4034294 | + | 1086 | Protein_4113 | cadaverine/lysine antiporter | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | htpB | 4005369..4066838 | 61469 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12492.40 Da Isoelectric Point: 5.5572
>T95863 WP_000239577.1 NZ_CP026780:4030675-4031025 [Shigella dysenteriae]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE
Download Length: 351 bp
>T95863 NZ_CP026780:4030675-4031025 [Shigella dysenteriae]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTTGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTTGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9315.64 Da Isoelectric Point: 4.4201
>AT95863 WP_001223211.1 NZ_CP026780:4030430-4030681 [Shigella dysenteriae]
MRITIKRWGNSAGMVIPNVVMKELNLWPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW
MRITIKRWGNSAGMVIPNVVMKELNLWPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW
Download Length: 252 bp
>AT95863 NZ_CP026780:4030430-4030681 [Shigella dysenteriae]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTATG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGTTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCTACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTATG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGTTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCTACCCCTGCGGGTGAC
GAAATATGGTAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | U9XNP6 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2X2I2M3 |