Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2790324..2790978 Replicon chromosome
Accession NZ_CP026780
Organism Shigella dysenteriae strain 53-3937

Toxin (Protein)


Gene name cptA Uniprot ID Q32BV9
Locus tag C1P63_RS15430 Protein ID WP_000244779.1
Coordinates 2790571..2790978 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C1P63_RS15425 Protein ID WP_000354046.1
Coordinates 2790324..2790590 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P63_RS15400 2785638..2787071 - 1434 Protein_2876 6-phospho-beta-glucosidase BglA -
C1P63_RS15405 2787116..2787427 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
C1P63_RS15415 2788428..2789024 + 597 Protein_2879 hemolysin III family protein -
C1P63_RS15420 2789101..2790081 - 981 WP_000886092.1 tRNA-modifying protein YgfZ -
C1P63_RS15425 2790324..2790590 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C1P63_RS15430 2790571..2790978 + 408 WP_000244779.1 protein YgfX Toxin
C1P63_RS15435 2791018..2791539 - 522 WP_001055874.1 flavodoxin FldB -
C1P63_RS15440 2791651..2792547 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
C1P63_RS15445 2792572..2793282 + 711 WP_000715209.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P63_RS15450 2793288..2795020 + 1733 Protein_2886 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2787676..2788071 395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.2669

>T95861 WP_000244779.1 NZ_CP026780:2790571-2790978 [Shigella dysenteriae]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRWILLQQETQR

Download         Length: 408 bp

>T95861 NZ_CP026780:2790571-2790978 [Shigella dysenteriae]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGTGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT95861 WP_000354046.1 NZ_CP026780:2790324-2790590 [Shigella dysenteriae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT95861 NZ_CP026780:2790324-2790590 [Shigella dysenteriae]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NWM4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References