Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3141458..3142256 | Replicon | chromosome |
| Accession | NZ_CP026777 | ||
| Organism | Shigella dysenteriae strain 69-3818 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q32HN1 |
| Locus tag | C5C01_RS16930 | Protein ID | WP_001094433.1 |
| Coordinates | 3141458..3141832 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | Q32HN0 |
| Locus tag | C5C01_RS16935 | Protein ID | WP_001285603.1 |
| Coordinates | 3141879..3142256 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C5C01_RS16895 | 3137045..3137599 | - | 555 | WP_001001927.1 | molecular chaperone YcdY | - |
| C5C01_RS16900 | 3137623..3138359 | - | 737 | Protein_3174 | zinc-binding phosphatase | - |
| C5C01_RS16905 | 3138414..3139351 | - | 938 | Protein_3175 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| C5C01_RS16915 | 3139822..3140664 | - | 843 | WP_005020348.1 | DUF4942 domain-containing protein | - |
| C5C01_RS16920 | 3140761..3140958 | - | 198 | WP_119164595.1 | DUF957 domain-containing protein | - |
| C5C01_RS16925 | 3140970..3141461 | - | 492 | WP_000976859.1 | hypothetical protein | - |
| C5C01_RS16930 | 3141458..3141832 | - | 375 | WP_001094433.1 | toxin | Toxin |
| C5C01_RS16935 | 3141879..3142256 | - | 378 | WP_001285603.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| C5C01_RS16940 | 3142306..3142950 | - | 645 | WP_000086764.1 | hypothetical protein | - |
| C5C01_RS16945 | 3142969..3143190 | - | 222 | WP_000692331.1 | DUF987 domain-containing protein | - |
| C5C01_RS16950 | 3143259..3143711 | - | 453 | WP_001186198.1 | RadC family protein | - |
| C5C01_RS16955 | 3143727..3144200 | - | 474 | WP_001313575.1 | antirestriction protein | - |
| C5C01_RS16965 | 3144480..3145300 | - | 821 | Protein_3185 | DUF945 domain-containing protein | - |
| C5C01_RS16975 | 3145401..3145574 | - | 174 | WP_000088742.1 | DUF905 family protein | - |
| C5C01_RS16980 | 3145694..3146177 | - | 484 | Protein_3187 | hypothetical protein | - |
| C5C01_RS16985 | 3146608..3147075 | - | 468 | WP_000668907.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | iroN / iroN / iroE / iroD / iroD / iroC / iroB / rcsA / ipaH9.8 / ipaH9.8 / fliC / fliA / flhD / flhC / motA / motB / motB / flhA | 3135706..3327694 | 191988 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13918.86 Da Isoelectric Point: 6.8517
>T95835 WP_001094433.1 NZ_CP026777:c3141832-3141458 [Shigella dysenteriae]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSPLINSIDILRARRVTGLMTRDNYRTVNNITLGKHPEAK
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSPLINSIDILRARRVTGLMTRDNYRTVNNITLGKHPEAK
Download Length: 375 bp
>T95835 NZ_CP026777:c3141832-3141458 [Shigella dysenteriae]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCCGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGTGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCCGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGTGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13789.72 Da Isoelectric Point: 6.4643
>AT95835 WP_001285603.1 NZ_CP026777:c3142256-3141879 [Shigella dysenteriae]
VSDTLPGTTLPDDNKDRPWWRLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTLPDDNKDRPWWRLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT95835 NZ_CP026777:c3142256-3141879 [Shigella dysenteriae]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGATAACAAAGACCGCCCCTGGTGGAGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGATAACAAAGACCGCCCCTGGTGGAGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A090NBY3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A090NW75 |