95831

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1999049..1999644 Replicon chromosome
Accession NZ_CP026777
Organism Shigella dysenteriae strain 69-3818

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag C5C01_RS10785 Protein ID WP_000239577.1
Coordinates 1999294..1999644 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2X2I2M3
Locus tag C5C01_RS10780 Protein ID WP_001223211.1
Coordinates 1999049..1999300 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5C01_RS10770 1994714..1998493 + 3780 WP_000060952.1 autotransporter assembly complex protein TamB -
C5C01_RS10775 1998496..1998837 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
C5C01_RS10780 1999049..1999300 + 252 WP_001223211.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
C5C01_RS10785 1999294..1999644 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
C5C01_RS10790 1999721..2000251 - 531 WP_000055075.1 inorganic diphosphatase -
C5C01_RS10795 2000561..2001061 + 501 Protein_2021 galactofuranose ABC transporter substrate-binding protein YtfQ -
C5C01_RS10805 2001828..2002913 + 1086 Protein_2023 cadaverine/lysine antiporter -
C5C01_RS10810 2002993..2003274 + 282 Protein_2024 lysine decarboxylase LdcC -
C5C01_RS10815 2003291..2003988 - 698 Protein_2025 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T95831 WP_000239577.1 NZ_CP026777:1999294-1999644 [Shigella dysenteriae]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T95831 NZ_CP026777:1999294-1999644 [Shigella dysenteriae]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTTGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9315.64 Da        Isoelectric Point: 4.4201

>AT95831 WP_001223211.1 NZ_CP026777:1999049-1999300 [Shigella dysenteriae]
MRITIKRWGNSAGMVIPNVVMKELNLWPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT95831 NZ_CP026777:1999049-1999300 [Shigella dysenteriae]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTATG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCTACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2I2M3

References