Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 154515..155074 Replicon plasmid unnamed
Accession NZ_CP026775
Organism Shigella dysenteriae strain ATCC 13313

Toxin (Protein)


Gene name relE Uniprot ID Q327A7
Locus tag C1P61_RS24950 Protein ID WP_000421263.1
Coordinates 154515..154790 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q327A8
Locus tag C1P61_RS24955 Protein ID WP_001178088.1
Coordinates 154790..155074 (-) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P61_RS24915 150155..150250 - 96 Protein_173 transposase domain-containing protein -
C1P61_RS24920 150286..150591 - 306 WP_001159860.1 type II toxin-antitoxin system toxin CcdB -
C1P61_RS24925 150593..150811 - 219 WP_000813626.1 type II toxin-antitoxin system antitoxin CcdA -
C1P61_RS24930 151051..151744 + 694 Protein_176 IS1 family transposase -
C1P61_RS24935 152120..153210 - 1091 Protein_177 IS66 family transposase -
C1P61_RS24940 153218..153786 + 569 Protein_178 plasmid segregation protein ParM -
C1P61_RS24945 153789..154154 + 366 WP_000361390.1 plasmid partitioning/stability family protein -
C1P61_RS26485 154246..154383 + 138 WP_000766699.1 hypothetical protein -
C1P61_RS24950 154515..154790 - 276 WP_000421263.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1P61_RS24955 154790..155074 - 285 WP_001178088.1 ribbon-helix-helix domain-containing protein Antitoxin
C1P61_RS24970 155826..156035 + 210 Protein_183 peptidoglycan-binding protein -
C1P61_RS24975 156135..156348 - 214 Protein_184 ATP-binding protein -
C1P61_RS24985 156656..157125 + 470 Protein_185 IS1 family transposase -
C1P61_RS26490 157284..157922 + 639 WP_000607008.1 type III secretion system effector OspI -
C1P61_RS24995 158037..158570 + 534 Protein_187 transposase -
C1P61_RS26495 158625..158765 + 141 Protein_188 IS3 family transposase -
C1P61_RS25000 158830..159230 + 401 Protein_189 transposase -
C1P61_RS25005 159286..159983 + 698 Protein_190 IS1 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ospE2 / ipaH1.4 / ipaH7.8 / ipaH4.5 / ipgB2 / ospD1 / ospF / ospD2 / ospC2 / ospC4 / ospB / icsP/sopA / nleE / icsA/virG / virA / spa40 / spa40 / spa29 / spa9 / spa24 / spa33 / spa32 / spa13 / spa47 / spa15 / mxiA / mxiC / mxiD / mxiE / mxiM / mxiL / mxiN / mxiK / mxiJ / mxiI / mxiH / mxiG / ipgF / ipgE / ipgD / icsB / ipgA / ipgB1 / ipgC / ipaB / ipaC / ipaD / ipaA / ipaJ / ospC3 / ospG / ipaH9.8 / ospI / ospC2 / ospD3/senA / ospC1 1..182697 182697
- inside IScluster/Tn - ospG / ipaH9.8 / ospI / ospC2 144131..174332 30201


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 92 a.a.        Molecular weight: 10792.51 Da        Isoelectric Point: 9.8135

>T95802 WP_000421263.1 NZ_CP026775:c154790-154515 [Shigella dysenteriae]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWYTRENR

Download         Length: 276 bp

>T95802 NZ_CP026775:c154790-154515 [Shigella dysenteriae]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTAGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGTACACACGAGAGAACAGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10497.93 Da        Isoelectric Point: 6.2150

>AT95802 WP_001178088.1 NZ_CP026775:c155074-154790 [Shigella dysenteriae]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR

Download         Length: 285 bp

>AT95802 NZ_CP026775:c155074-154790 [Shigella dysenteriae]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q327A7


Antitoxin

Source ID Structure
AlphaFold DB Q327A8

References