Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
Location | 154515..155074 | Replicon | plasmid unnamed |
Accession | NZ_CP026775 | ||
Organism | Shigella dysenteriae strain ATCC 13313 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q327A7 |
Locus tag | C1P61_RS24950 | Protein ID | WP_000421263.1 |
Coordinates | 154515..154790 (-) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q327A8 |
Locus tag | C1P61_RS24955 | Protein ID | WP_001178088.1 |
Coordinates | 154790..155074 (-) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C1P61_RS24915 | 150155..150250 | - | 96 | Protein_173 | transposase domain-containing protein | - |
C1P61_RS24920 | 150286..150591 | - | 306 | WP_001159860.1 | type II toxin-antitoxin system toxin CcdB | - |
C1P61_RS24925 | 150593..150811 | - | 219 | WP_000813626.1 | type II toxin-antitoxin system antitoxin CcdA | - |
C1P61_RS24930 | 151051..151744 | + | 694 | Protein_176 | IS1 family transposase | - |
C1P61_RS24935 | 152120..153210 | - | 1091 | Protein_177 | IS66 family transposase | - |
C1P61_RS24940 | 153218..153786 | + | 569 | Protein_178 | plasmid segregation protein ParM | - |
C1P61_RS24945 | 153789..154154 | + | 366 | WP_000361390.1 | plasmid partitioning/stability family protein | - |
C1P61_RS26485 | 154246..154383 | + | 138 | WP_000766699.1 | hypothetical protein | - |
C1P61_RS24950 | 154515..154790 | - | 276 | WP_000421263.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
C1P61_RS24955 | 154790..155074 | - | 285 | WP_001178088.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
C1P61_RS24970 | 155826..156035 | + | 210 | Protein_183 | peptidoglycan-binding protein | - |
C1P61_RS24975 | 156135..156348 | - | 214 | Protein_184 | ATP-binding protein | - |
C1P61_RS24985 | 156656..157125 | + | 470 | Protein_185 | IS1 family transposase | - |
C1P61_RS26490 | 157284..157922 | + | 639 | WP_000607008.1 | type III secretion system effector OspI | - |
C1P61_RS24995 | 158037..158570 | + | 534 | Protein_187 | transposase | - |
C1P61_RS26495 | 158625..158765 | + | 141 | Protein_188 | IS3 family transposase | - |
C1P61_RS25000 | 158830..159230 | + | 401 | Protein_189 | transposase | - |
C1P61_RS25005 | 159286..159983 | + | 698 | Protein_190 | IS1 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | ospE2 / ipaH1.4 / ipaH7.8 / ipaH4.5 / ipgB2 / ospD1 / ospF / ospD2 / ospC2 / ospC4 / ospB / icsP/sopA / nleE / icsA/virG / virA / spa40 / spa40 / spa29 / spa9 / spa24 / spa33 / spa32 / spa13 / spa47 / spa15 / mxiA / mxiC / mxiD / mxiE / mxiM / mxiL / mxiN / mxiK / mxiJ / mxiI / mxiH / mxiG / ipgF / ipgE / ipgD / icsB / ipgA / ipgB1 / ipgC / ipaB / ipaC / ipaD / ipaA / ipaJ / ospC3 / ospG / ipaH9.8 / ospI / ospC2 / ospD3/senA / ospC1 | 1..182697 | 182697 | |
- | inside | IScluster/Tn | - | ospG / ipaH9.8 / ospI / ospC2 | 144131..174332 | 30201 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10792.51 Da Isoelectric Point: 9.8135
>T95802 WP_000421263.1 NZ_CP026775:c154790-154515 [Shigella dysenteriae]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWYTRENR
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWYTRENR
Download Length: 276 bp
>T95802 NZ_CP026775:c154790-154515 [Shigella dysenteriae]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTAGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGTACACACGAGAGAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTAGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGTACACACGAGAGAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10497.93 Da Isoelectric Point: 6.2150
>AT95802 WP_001178088.1 NZ_CP026775:c155074-154790 [Shigella dysenteriae]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
Download Length: 285 bp
>AT95802 NZ_CP026775:c155074-154790 [Shigella dysenteriae]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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