Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3320860..3321514 Replicon chromosome
Accession NZ_CP026774
Organism Shigella dysenteriae strain ATCC 13313

Toxin (Protein)


Gene name cptA Uniprot ID Q32BV9
Locus tag C1P61_RS18285 Protein ID WP_000244779.1
Coordinates 3320860..3321267 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C1P61_RS18290 Protein ID WP_000354046.1
Coordinates 3321248..3321514 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P61_RS18265 3316817..3318550 - 1734 WP_000813170.1 single-stranded-DNA-specific exonuclease RecJ -
C1P61_RS18270 3318556..3319266 - 711 WP_000715209.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P61_RS18275 3319291..3320187 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
C1P61_RS18280 3320299..3320820 + 522 WP_001055874.1 flavodoxin FldB -
C1P61_RS18285 3320860..3321267 - 408 WP_000244779.1 protein YgfX Toxin
C1P61_RS18290 3321248..3321514 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C1P61_RS18295 3321757..3322737 + 981 WP_000886092.1 tRNA-modifying protein YgfZ -
C1P61_RS18300 3322814..3323410 - 597 Protein_3413 hemolysin III family protein -
C1P61_RS18305 3323468..3324162 + 695 WP_087786203.1 IS1-like element IS1N family transposase -
C1P61_RS18310 3324411..3324722 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
C1P61_RS18315 3324767..3326200 + 1434 Protein_3416 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3323767..3324162 395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.2669

>T95796 WP_000244779.1 NZ_CP026774:c3321267-3320860 [Shigella dysenteriae]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRWILLQQETQR

Download         Length: 408 bp

>T95796 NZ_CP026774:c3321267-3320860 [Shigella dysenteriae]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGTGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT95796 WP_000354046.1 NZ_CP026774:c3321514-3321248 [Shigella dysenteriae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT95796 NZ_CP026774:c3321514-3321248 [Shigella dysenteriae]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NWM4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References