Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2081177..2081772 Replicon chromosome
Accession NZ_CP026774
Organism Shigella dysenteriae strain ATCC 13313

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag C1P61_RS11660 Protein ID WP_000239577.1
Coordinates 2081177..2081527 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2X2I2M3
Locus tag C1P61_RS11665 Protein ID WP_001223211.1
Coordinates 2081521..2081772 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P61_RS11640 2077908..2078993 - 1086 Protein_2178 cadaverine/lysine antiporter -
C1P61_RS11645 2079052..2079746 + 695 WP_087786203.1 IS1-like element IS1N family transposase -
C1P61_RS11650 2079760..2080260 - 501 Protein_2180 galactofuranose ABC transporter substrate-binding protein YtfQ -
C1P61_RS11655 2080570..2081100 + 531 WP_000055075.1 inorganic diphosphatase -
C1P61_RS11660 2081177..2081527 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
C1P61_RS11665 2081521..2081772 - 252 WP_001223211.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
C1P61_RS11670 2081984..2082325 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
C1P61_RS11675 2082328..2086107 - 3780 WP_000060952.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - htpB 2045364..2098337 52973


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T95794 WP_000239577.1 NZ_CP026774:c2081527-2081177 [Shigella dysenteriae]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T95794 NZ_CP026774:c2081527-2081177 [Shigella dysenteriae]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTTGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9315.64 Da        Isoelectric Point: 4.4201

>AT95794 WP_001223211.1 NZ_CP026774:c2081772-2081521 [Shigella dysenteriae]
MRITIKRWGNSAGMVIPNVVMKELNLWPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT95794 NZ_CP026774:c2081772-2081521 [Shigella dysenteriae]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTATG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCTACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2I2M3

References