Detailed information of TA system TA095791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): itaRT/DUF1778(antitoxin)
• Location: 1585784..1586621
• Replicon: chromosome
• Accession: NZ_CP026774
• Organism: Shigella dysenteriae strain ATCC 13313

Toxin (Protein)

• Gene name: itaT
• Uniprot ID: -
• Locus tag: C1P61_RS09005
• Protein ID: WP_134801624.1
• Coordinates: 1585784..1586326 (-)
• Length: 181 a.a.

Antitoxin (Protein)

• Gene name: itaR
• Uniprot ID: -
• Locus tag: C1P61_RS09010
• Protein ID: WP_134801623.1
• Coordinates: 1586310..1586621 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P61_RS08965	1580897..1581591	+	695	WP_134801577.1	IS1-like element IS1N family transposase	-
C1P61_RS08970	1581978..1582601	+	624	Protein_1677	sel1 repeat family protein	-
C1P61_RS08975	1582645..1583481	-	837	Protein_1678	IS3-like element IS600 family transposase	-
C1P61_RS08980	1583539..1584233	+	695	WP_134801625.1	IS1 family transposase	-
C1P61_RS08985	1584250..1584575	-	326	Protein_1680	transposase	-
C1P61_RS09000	1585510..1585728	+	219	Protein_1682	hypothetical protein	-
C1P61_RS09005	1585784..1586326	-	543	WP_134801624.1	GNAT family N-acetyltransferase	Toxin
C1P61_RS09010	1586310..1586621	-	312	WP_134801623.1	DUF1778 domain-containing protein	Antitoxin
C1P61_RS09015	1586806..1587696	-	891	WP_134801622.1	heme o synthase	-
C1P61_RS09020	1587708..1588037	-	330	WP_000019869.1	cytochrome o ubiquinol oxidase subunit IV	-
C1P61_RS09025	1588037..1588651	-	615	WP_134801621.1	cytochrome o ubiquinol oxidase subunit III	-
C1P61_RS09030	1588641..1590630	-	1990	Protein_1688	cytochrome o ubiquinol oxidase subunit I	-
C1P61_RS09035	1590652..1591599	-	948	WP_134801620.1	cytochrome o ubiquinol oxidase subunit II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1580897..1611593	30696

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (68-156)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-97)

Sequences

Toxin

Protein

• Length: 181 a.a.
• Molecular weight: 19739.89 Da
• Isoelectric Point: 8.1380

>T95791 WP_134801624.1 NZ_CP026774:c1586326-1585784 [Shigella dysenteriae]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVHASLKKSVRNSDGAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Nucleotide

• Length: 543 bp

>T95791 NZ_CP026774:c1586326-1585784 [Shigella dysenteriae]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACACGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACG
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCGCG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGAGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11497.20 Da
• Isoelectric Point: 10.6770

>AT95791 WP_134801623.1 NZ_CP026774:c1586621-1586310 [Shigella dysenteriae]
MPRKTATLHDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Nucleotide

• Length: 312 bp

>AT95791 NZ_CP026774:c1586621-1586310 [Shigella dysenteriae]
ATGCCTAGAAAAACAGCCACTCTACACGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACACTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA