Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 922585..923383 Replicon chromosome
Accession NZ_CP026774
Organism Shigella dysenteriae strain ATCC 13313

Toxin (Protein)


Gene name yeeV Uniprot ID Q32HN1
Locus tag C1P61_RS05415 Protein ID WP_001094433.1
Coordinates 923009..923383 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q32HN0
Locus tag C1P61_RS05410 Protein ID WP_001285603.1
Coordinates 922585..922962 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P61_RS05360 917765..918232 + 468 WP_000668907.1 hypothetical protein -
C1P61_RS05365 918663..919146 + 484 Protein_1000 hypothetical protein -
C1P61_RS05370 919266..919439 + 174 WP_000088742.1 DUF905 family protein -
C1P61_RS05380 919540..920361 + 822 WP_001234573.1 DUF945 domain-containing protein -
C1P61_RS05390 920641..921114 + 474 WP_001313575.1 antirestriction protein -
C1P61_RS05395 921130..921582 + 453 WP_001186198.1 RadC family protein -
C1P61_RS05400 921651..921872 + 222 WP_000692331.1 DUF987 domain-containing protein -
C1P61_RS05405 921891..922535 + 645 WP_000086764.1 hypothetical protein -
C1P61_RS05410 922585..922962 + 378 WP_001285603.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C1P61_RS05415 923009..923383 + 375 WP_001094433.1 toxin Toxin
C1P61_RS05420 923380..923871 + 492 WP_000976859.1 hypothetical protein -
C1P61_RS05425 923883..924080 + 198 WP_000839257.1 DUF957 domain-containing protein -
C1P61_RS05430 924177..925019 + 843 WP_005020348.1 DUF4942 domain-containing protein -
C1P61_RS05440 925490..926428 + 939 WP_000351336.1 glyoxylate/hydroxypyruvate reductase GhrA -
C1P61_RS05445 926483..927220 + 738 WP_000283663.1 zinc-binding phosphatase -
C1P61_RS05450 927244..927798 + 555 WP_001001927.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13918.86 Da        Isoelectric Point: 6.8517

>T95789 WP_001094433.1 NZ_CP026774:923009-923383 [Shigella dysenteriae]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSPLINSIDILRARRVTGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T95789 NZ_CP026774:923009-923383 [Shigella dysenteriae]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCCGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGTGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13789.72 Da        Isoelectric Point: 6.4643

>AT95789 WP_001285603.1 NZ_CP026774:922585-922962 [Shigella dysenteriae]
VSDTLPGTTLPDDNKDRPWWRLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT95789 NZ_CP026774:922585-922962 [Shigella dysenteriae]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGATAACAAAGACCGCCCCTGGTGGAGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NBY3

Antitoxin

Source ID Structure
AlphaFold DB A0A090NW75

References