Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4087033..4087687 Replicon chromosome
Accession NZ_CP026768
Organism Shigella flexneri Y strain 93-3063

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag C1P87_RS20970 Protein ID WP_000244767.1
Coordinates 4087280..4087687 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag C1P87_RS20965 Protein ID WP_000354044.1
Coordinates 4087033..4087299 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P87_RS20940 4082203..4082946 + 744 WP_000951957.1 SDR family oxidoreductase -
C1P87_RS20945 4083003..4084436 - 1434 WP_005076748.1 6-phospho-beta-glucosidase BglA -
C1P87_RS20950 4084481..4084791 + 311 Protein_4069 N(4)-acetylcytidine aminohydrolase -
C1P87_RS20955 4084955..4085614 + 660 WP_000250274.1 hemolysin III family protein -
C1P87_RS20960 4085810..4086790 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
C1P87_RS20965 4087033..4087299 + 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
C1P87_RS20970 4087280..4087687 + 408 WP_000244767.1 protein YgfX Toxin
C1P87_RS20975 4087727..4088248 - 522 WP_001055867.1 flavodoxin FldB -
C1P87_RS20980 4088360..4089256 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
C1P87_RS20985 4089281..4089991 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P87_RS20990 4089997..4091730 + 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T95774 WP_000244767.1 NZ_CP026768:4087280-4087687 [Shigella flexneri Y]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T95774 NZ_CP026768:4087280-4087687 [Shigella flexneri Y]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT95774 WP_000354044.1 NZ_CP026768:4087033-4087299 [Shigella flexneri Y]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT95774 NZ_CP026768:4087033-4087299 [Shigella flexneri Y]
ATGGACATTAACAACAAAGCCCGAATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References