Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2693287..2694119 | Replicon | chromosome |
| Accession | NZ_CP026768 | ||
| Organism | Shigella flexneri Y strain 93-3063 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PD64 |
| Locus tag | C1P87_RS14085 | Protein ID | WP_000854753.1 |
| Coordinates | 2693745..2694119 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | V0ULY5 |
| Locus tag | C1P87_RS14080 | Protein ID | WP_001315620.1 |
| Coordinates | 2693287..2693655 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C1P87_RS14050 (2690095) | 2690095..2690550 | + | 456 | WP_000581498.1 | IrmA family protein | - |
| C1P87_RS26865 (2690629) | 2690629..2690784 | + | 156 | WP_001119723.1 | DUF905 family protein | - |
| C1P87_RS14060 (2690963) | 2690963..2691784 | + | 822 | WP_001234562.1 | DUF932 domain-containing protein | - |
| C1P87_RS14065 (2691839) | 2691839..2692324 | + | 486 | WP_000849588.1 | antirestriction protein | - |
| C1P87_RS14070 (2692340) | 2692340..2692816 | + | 477 | WP_001186725.1 | RadC family protein | - |
| C1P87_RS14075 (2692903) | 2692903..2693124 | + | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| C1P87_RS14080 (2693287) | 2693287..2693655 | + | 369 | WP_001315620.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| C1P87_RS14085 (2693745) | 2693745..2694119 | + | 375 | WP_000854753.1 | TA system toxin CbtA family protein | Toxin |
| C1P87_RS14090 (2694116) | 2694116..2694604 | + | 489 | WP_000777547.1 | DUF5983 family protein | - |
| C1P87_RS14095 (2694616) | 2694616..2694813 | + | 198 | WP_000839281.1 | DUF957 domain-containing protein | - |
| C1P87_RS26205 (2694898) | 2694898..2695047 | + | 150 | Protein_2738 | restriction endonuclease subunit M | - |
| C1P87_RS14110 (2695512) | 2695512..2696723 | + | 1212 | WP_001218324.1 | integrase arm-type DNA-binding domain-containing protein | - |
| C1P87_RS14120 (2697957) | 2697957..2698043 | + | 87 | Protein_2741 | DUF3811 domain-containing protein | - |
| C1P87_RS14130 (2698655) | 2698655..2698960 | + | 306 | WP_005111853.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | fimB / fimE | 2678302..2710143 | 31841 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14005.00 Da Isoelectric Point: 8.2905
>T95772 WP_000854753.1 NZ_CP026768:2693745-2694119 [Shigella flexneri Y]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T95772 NZ_CP026768:2693745-2694119 [Shigella flexneri Y]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13474.20 Da Isoelectric Point: 6.2050
>AT95772 WP_001315620.1 NZ_CP026768:2693287-2693655 [Shigella flexneri Y]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT95772 NZ_CP026768:2693287-2693655 [Shigella flexneri Y]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGATCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTACTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGATCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTACTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LVU0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0ULY5 |