Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 96942..97717 Replicon plasmid unnamed
Accession NZ_CP026767
Organism Shigella boydii strain 59-248

Toxin (Protein)


Gene name tacT Uniprot ID Q31SE5
Locus tag C1P58_RS25145 Protein ID WP_000405246.1
Coordinates 97235..97717 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q7BEG8
Locus tag C1P58_RS25140 Protein ID WP_010921625.1
Coordinates 96942..97244 (+) Length 101 a.a.

Genomic Context

C1P58_RS25110C1P58_RS25140C1P58_RS25145C1P58_RS25155C1P58_RS25165C1P58_RS25175C1P58_RS25105C1P58_RS25965C1P58_RS25125C1P58_RS25130C1P58_RS25150C1P58_RS25160C1P58_RS25170
Location: 93306..94760 (1455 bp)
Type: Others
Protein ID: WP_000701110.1
Location: 96942..97244 (303 bp)
Type: Antitoxin
Protein ID: WP_010921625.1
Location: 97235..97717 (483 bp)
Type: Toxin
Protein ID: WP_000405246.1
Location: 98561..99084 (524 bp)
Type: Others
Protein ID: Protein_112
Location: 99539..100707 (1169 bp)
Type: Others
Protein ID: WP_094096743.1
Location: 101479..101631 (153 bp)
Type: Others
Protein ID: Protein_116
Location: 92037..92881 (845 bp)
Type: Others
Protein ID: Protein_104
Location: 94909..95037 (129 bp)
Type: Others
Protein ID: Protein_106
Location: 95209..96417 (1209 bp)
Type: Others
Protein ID: WP_134802528.1
Location: 96398..96670 (273 bp)
Type: Others
Protein ID: WP_000019158.1
Location: 97803..98500 (698 bp)
Type: Others
Protein ID: Protein_111
Location: 99127..99465 (339 bp)
Type: Others
Protein ID: Protein_113
Location: 100731..101423 (693 bp)
Type: Others
Protein ID: WP_073832157.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1P58_RS2510592037..92881-845Protein_104IS5 family transposase-
C1P58_RS2511093306..94760+1455WP_000701110.1type 3 secretion system effector OspC2-
C1P58_RS2596594909..95037-129Protein_106IS5/IS1182 family transposase-
C1P58_RS2512595209..96417-1209WP_134802528.1IS91 family transposase-
C1P58_RS2513096398..96670-273WP_000019158.1hypothetical protein-
C1P58_RS2514096942..97244+303WP_010921625.1DUF1778 domain-containing proteinAntitoxin
C1P58_RS2514597235..97717+483WP_000405246.1GNAT family N-acetyltransferaseToxin
C1P58_RS2515097803..98500-698Protein_111IS1 family transposase-
C1P58_RS2515598561..99084+524Protein_112transposase-
C1P58_RS2516099127..99465-339Protein_113transposase-
C1P58_RS2516599539..100707+1169WP_094096743.1IS3 family transposase-
C1P58_RS25170100731..101423-693WP_073832157.1type III secretion system effector cysteine methyltransferase OspZ-
C1P58_RS25175101479..101631+153Protein_116IS3 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-ospI / ospI / ospC3 / ipaJ / ipaA / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / virA / icsA/virG / papC / ipaH9.8 / ospC2 / nleE / icsP/sopA / ospB / ospC3 / ospC4 / ospD2 / ospF / ospD1 / ipgB2 / ipaH1.4 / ipaH4.5 / ipaH7.8 / ospD3/senA / ospC1 / senB / ospE2 / ospI / ospC3 / ipaJ / ipaA / ipaA / ipaA / ipaD1..209166209166
-insideIScluster/Tn-ospC2 / nleE / icsP/sopA / ospB / ospC3 / ospC4 / ospD2 / ospF / ospD1 / ipgB290772..13657045798


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(29-149)

Antitoxin

Vibrio phage ICP1, Orf50

(19-94)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17748.55 Da        Isoelectric Point: 7.0382

>T95755 WP_000405246.1 NZ_CP026767:97235-97717 [Shigella boydii]
MEINVTAPALLTDEHILQPFDCGNEVLSNWLRGRAMKNQMLNASRTFVICLEDTLRVVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCIQGHGFGKWLLSDAIHRVVNLADQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPNTLFYKV

Download         Length: 483 bp

>T95755 NZ_CP026767:97235-97717 [Shigella boydii]
ATGGAAATAAATGTCACCGCGCCAGCATTGTTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCTCGCACGTTCGTTATTTGCTTGGAGGATA
CTTTACGTGTTGTGGGATACTACTCATTAGCTACTGGTTCCGTCACTCATGCCGAGCTTGGTCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTCCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTATCCAGGGGCATGGTTTCGGTAAATG
GCTACTAAGTGATGCCATTCACCGGGTTGTCAATCTGGCTGATCAGGTTGGCATTAAGGCTGTTATGGTACATGCAATTG
ATGATGACGCCAGAGCATTTTATGAGCGTTTTGGTTTTGTTCAGTCAGTTGTGGCACCTAATACCTTGTTTTATAAAGTC
TGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11689.28 Da        Isoelectric Point: 4.9167

>AT95755 WP_010921625.1 NZ_CP026767:96942-97244 [Shigella boydii]
MEVFMSTAASVRKTPREHQINIRATDEERAVIDYAASLVNKNRTDFIMELAYQEAKNIILDQRLFVLDNERYDSFITQLE
APVQNAEGRERLMAVKPEWK

Download         Length: 303 bp

>AT95755 NZ_CP026767:96942-97244 [Shigella boydii]
ATGGAGGTTTTTATGTCTACAGCTGCAAGCGTCCGTAAAACACCGCGAGAACATCAGATTAACATCCGGGCAACTGATGA
GGAACGAGCCGTTATTGATTATGCTGCGAGCTTGGTCAATAAGAACCGTACCGATTTCATCATGGAACTGGCGTACCAGG
AAGCTAAAAACATTATCCTGGATCAACGTTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAA
GCTCCTGTGCAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ31SE5

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7BEG8

References